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Neuropeptide Y Receptor 1 antibody

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Anti Human Neuropeptide Y Receptor 1 Antibody thumbnail image 1 Anti Human Neuropeptide Y Receptor 1 Antibody thumbnail image 2 Anti Human Neuropeptide Y Receptor 1 Antibody thumbnail image 3
Anti Human Neuropeptide Y Receptor 1 Antibody gallery image 1
Human brain lysate probed with Sheep anti Human Neuropeptide Y Receptor 1 antibody (6732-0150).
Anti Human Neuropeptide Y Receptor 1 Antibody gallery image 2
Published customer image:
Sheep anti Human neuropeptide Y receptor 1 antibody (6732-0150) used for the detection of NY1R in rat retinal ganglion cells by immunofluorescence.
Image caption:
.NPY and NPY receptor immunoreactivity (ir) in a purified RGC culture obtained from Wistar pups (a–e, red). RGCs were stained with antiBrn3a (RGC marker, green) and nuclei with DAPI (blue). Scale bar: 20 μm.

From: Martins J, Elvas F, Brudzewsky D, Martins T, Kolomiets B, Tralhão P, Gøtzsche CR, Cavadas C, Castelo-Branco M, Woldbye DP, Picaud S, Santiago AR, Ambrósio AF. Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiologyand Exerts Neuroprotective Actions In Vitro.
ASN Neuro. 2015 Aug 26;7(4). pii:1759091415598292.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Anti Human Neuropeptide Y Receptor 1 Antibody gallery image 3
Published customer image:
Sheep anti Human neuropeptide Y receptor 1 antibody (6732-0150) used for the detection of NY1R in rat retinal ganglion cells by immunogluorescence.
Image caption:
.NPY-ir and NPY receptor-ir in retinal slices obtained from young adult Wistar rats (a–e, red). RGCs were stained with the RGC marker Brn3a (green) and nuclei with DAPI (blue). NPY-ir was mainly detected in strata 1, 3, and 5 of IPL (arrows; a). Y1-ir was detected in distal and proximal INL, strata 2 and 4 of IPL, and RGCs (arrows; b). Y2-ir was detected in INL (c). Y4-ir was detected in INL and GCL (d). and Y5-ir was detected in Müller cells (e). (d) Y5-ir (red) is colocalized with Müller cells (green) in retinal slices of young adult Wistar rats. Müller cells were identified by vimentin-ir (green). Nuclei were stained with DAPI (blue). GCL = ganglion cell layer; IPL = inner plexiform layer; INL = inner nuclear layer; OPL = outer plexiform layer; ONL = outer nuclear layer. Scale bar: 50 μm.

From: Martins J, Elvas F, Brudzewsky D, Martins T, Kolomiets B, Tralhão P, Gøtzsche CR, Cavadas C, Castelo-Branco M, Woldbye DP, Picaud S, Santiago AR, Ambrósio AF. Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.
ASN Neuro. 2015 Aug 26;7(4). pii:1759091415598292.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.

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WB IF

Sheep anti Human Neuropeptide Y Receptor 1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Neuropeptide Y Receptor 1

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Product Code Applications Pack Size List Price Your Price Qty
6732-0150
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SDS Safety Datasheet SDS
E IF P * WB 1 ml loader
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Sheep anti Human Neuropeptide Y Receptor 1 antibody recognizes human neuropeptide Y receptor 1. Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
A synthetic peptide corresponding to amino acids 365 - 378 of human NPY1R, conjugated to KLH. Peptide sequence: KQASPVAFKKINNN
Approx. Protein Concentrations
IgG concentration 5.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunofluorescence
Immunohistology - Paraffin 1
Western Blotting 1/100 1/1000
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
6732-0150 detects a band of approximately 55 kDa in human brain.

Description Product Code Applications Pack Size List Price Your Price Quantity
Rabbit anti Sheep IgG (H/L):Biotin 5184-2304 C E F WB 1.5 ml loader
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Description Rabbit anti Sheep IgG (H/L):Biotin

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Antigen Retrieval Buffer, pH8.0 BUF025A P 500 ml
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Description Antigen Retrieval Buffer, pH8.0

References for Neuropeptide Y Receptor 1 antibody

  1. Decressac, M. et al. (2009) Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice.
    Neurobiol Dis. 34: 441-9.
  2. Ferreira, R. et al. (2010) Neuropeptide Y Modulation of Interleukin-1{beta} (IL-1{beta})-induced Nitric Oxide Production in Microglia.
    J Biol Chem. 285: 41921-34.
  3. Thiriet, N. et al. (2011) NPY promotes chemokinesis and neurogenesis in the rat subventricular zone.
    J Neurochem. 116 (6): 1018-27.
  4. Baptista, S. et al. (2012) Neuropeptide Y promotes neurogenesis and protection against methamphetamine-induced toxicity in mouse dentate gyrus-derived neurosphere cultures.
    Neuropharmacology. 62 (7): 2413-23.
  5. Martins, J. et al. (2015) Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.
    ASN Neuro.7(4):1759091415598292.
  6. Ventura, F. et al. (2020) Protective effect of neuropeptide Y2 receptor activation against methamphetamine-induced brain endothelial cell alterations.
    Toxicol Lett. 334: 53-59.

Immunofluorescence

Synonyms
NPY1R
RRID
AB_620417
UniProt
P25929
Entrez Gene
NPY1R
GO Terms
GO:0005515 protein binding
GO:0003151 outflow tract morphogenesis
GO:0005887 integral to plasma membrane
GO:0007193 inhibition of adenylate cyclase activity by G-protein signaling pathway

6732-0150

158803 1608

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