IGFBP-7 antibody

Rabbit anti Human IGFBP-7

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
IGFBP-7

Product Code Applications Pack Size List Price Your Price Qty
AHP1282
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E WB 0.1 mg loader
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loader
Search for Batch Specific Datasheets

Rabbit anti Human IGFBP-7 antibody recognizes human IGFBP-7 (insulin-like growth factor binding protein-7), also known as mac25, a 256 amino acid secreted protein and member of a growing family of IGFBPs which regulate the biological activities and distribution of the insulin-like growth factors (IGFs), through binding to IGF-I and IGF-II.

IGFBP-7 is widely expressed throughout normal tissues, but is also expressed in many tumour types at an increased or reduced level, and acts as a suppressor of breast and prostate cancer cell lines. IGFBP-7 inhibits IGF-induced differentiation of skeletal muscle (myogenesis) and has implications in bone formation, by its possible affects on the actions of parathyroid hormone (PTH) and cortisol.

Target Species
Human
Product Form
Purified IgG - lyophilized
Reconstitution
Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended.
Antiserum Preparation
Antisera to human IGFBP-7 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Carrier Free
Yes
Approx. Protein Concentrations
IgG concentration 1.0mg/ml after reconstitution.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.

This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 0.5 2.0ug/ml
Western Blotting 0.1 0.2ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
ELISA
This purified human IGFBP-7 antibody may be used in an ELISA recombinant human IGFBP-7 (PHP178) as the standard.

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Further Reading

  1. Ruan, W.J. et al. (2006) IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1.
    J Zhejiang Univ Sci B. 7 (11): 929-32.
  2. Pereira, R.C. & Canalis, E. (1999) Parathyroid hormone increases mac25/insulin-like growth factor-binding protein-related protein-1 expression in cultured osteoblasts.
    Endocrinology. 140 (5): 1998-2003.

Synonyms
Insulin-Like Growth Factor Binding PROTEIN-7
RRID
AB_2248672
UniProt
Q16270
Entrez Gene
IGFBP7
GO Terms
GO:0001558 regulation of cell growth
GO:0007155 cell adhesion
GO:0005520 insulin-like growth factor binding
GO:0005615 extracellular space
GO:0008285 negative regulation of cell proliferation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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