Histone H1.3 antibody
Rabbit anti Histone H1.3
- Product Type
- PrecisionAb Polyclonal
- Isotype
- Polyclonal IgG
- Format
- Purified
- Specificity
- Histone H1.3
Antibody Quality and Performance Guarantee
| Rabbit anti Human histone H1.3 antibody recognizes histone H1.3, also known as histone H1c, H1-3 and H1s-2. Histones are the major protein component of chromatin, with important roles in gene regulation. Histone H1 binds to linker DNA between nucleosomes, plays a role in higher-order chromatin stabilization, and is also able to fine-tune gene transcription in a locus-specific way (Brockers and Schneider, 2019). Histone variants replace canonical histones when nucleosomes are disrupted, with diverse implications for epigenetic gene regulation. Histone H1.3 is a histone variant and appears to have diverse roles in cancer. This protein has been suggested as a prognostic biomarker for pancreatic ductal adenocarcinoma (Bauden et al. 2017). Histone H1.3 has also been identified as a repressor for the oncogene H19, contributing to the suppression of epithelial ovarian carcinogenesis (Medrzycki et al. 2015). |
|
- Target Species
- Human
- Western Blotting
- Anti histone H1.3 antibody recognizes a band of approximately 30 kDa in Jurkat cell lysates.
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography on immunogen.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
2% Sucrose - Immunogen
- Synthetic peptide directed towards the N terminal region of human histone H1.3
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml.
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | E WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
- UniProt
- P16402
- Entrez Gene
- HIST1H1D
- GO Terms
- GO:0000786 nucleosome
- GO:0003677 DNA binding
- GO:0006334 nucleosome assembly
- GO:0005634 nucleus
VPA00783
170515
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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