Goat anti DPF2 antibody
recognizes zinc finger protein ubi-d4, also known as BAF45D, REQ, and UBID4.
DPF2 is a plant homeodomain (PHD) finger protein with roles in apoptosis, noncanonical NF-kappaB signaling and oncogenesis (Liu et al. 2015
). It acts as an adaptor protein, linking RelB/p52 with the SWI/SNF chromatin-remodeling complex (Shin et al. 2017). In human tissues, DPF2 is ubiquitously expressed but was discovered as being required for apoptosis in myeloid cells. Furthermore, this protein appears to play a role in inhibiting the differentiation of myeloid cells. DPF2 is associated with multiple human cancers including cervical cancer and acute myelogenous leukemia (AML) (Huber et al. 2017
). DPF2 also appears to play a role in influenza infection, with knockdown of DPF2 leading to decreased infectivity of the virus (Shin et al. 2017
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human DPF2 were raised by repeated immunizations of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
0.5% Bovine Serum Albumin
- Peptide with sequence C-QPPTPVSQRSEEQKS, from the internal region of the protein sequence according to NP_006259.1
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
nucleic acid binding
zinc ion binding
induction of apoptosis by extracellular signals
regulation of transcription
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of DPF2 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Goat anti Human DPF2 antibody detects a band of approximately 50 kDa and 48 kDa in cell lysates
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Secondary Antibodies Available
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