Cyclophilin B antibody
The protein encoded by PPIB gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporin A-mediated immunosuppression (provided by RefSeq, Oct 2009). Mutations in the PBIB gene lead to development of Osteogenesis imperfecta 9 (OI9) , a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma (van Dijk et al. 2009).
Rabbit anti Human cyclophilin B antibody detects a band of 20 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
- Target Species
- Western Blotting
- Anti cyclophilin B detects a band of approximately 20 kDa in A431 cell lysates.
- Species Cross-Reactivity
Target Species Cross Reactivity Mouse Rat
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid.
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Synthetic peptide directed towards the C terminal region of human cyclophilin B
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
- GO:0051082 unfolded protein binding
- GO:0006457 protein folding
- GO:0003755 peptidyl-prolyl cis-trans isomerase activity
- GO:0005788 endoplasmic reticulum lumen
- GO:0042277 peptide binding
- GO:0042470 melanosome
- PrecisionAb is a trademark of Bio-Rad Laboratories
- For research purposes only.
Applications of Cyclophilin B antibody
|Application Name||Verified||Min Dilution||Max Dilution|
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
Secondary Antibodies Available
|Description||Product Code||Applications||Pack Size||List Price||Quantity|
|Goat anti Rabbit IgG (H/L):HRP||STAR208P||WB||2 ml|
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