Collagen VII antibody

Rabbit anti Collagen VII

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
Collagen VII

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VPA00854
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Rabbit anti Human collagen VII antibody recognizes collagen VII, also known as LC collagen, collagen alpha-1(VII) chain, COL7A1 and long-chain collagen.

COL7A1 encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in COL7A1 are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen (provided by RefSeq, Jul 2008).

Rabbit anti Human collagen VII chain antibody detects a band of 295 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti collagen VII antibody recognizes a band of approximately 295 kDa in A431 cell lysates
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography on immunogen
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
<50% Glycerol
Immunogen
Recombinant protein of human collagen VII
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q02388
Entrez Gene
COL7A1
GO Terms
GO:0005515 protein binding
GO:0007155 cell adhesion
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005590 collagen type VII
GO:0005604 basement membrane
GO:0008544 epidermis development
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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