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|Goat anti Human CDK10 antibody recognizes cyclin-dependent kinase 10 (CDK10), also known as serine/threonine-protein kinase PISSLRE.
Cyclin-dependent kinases (CDKs) are serine/threonine kinases with activity regulated by specific cyclin partners, and by CDK inhibitors (CKIs). CDKs are well-known for controlling progression through the cell cycle, but also regulate many other cellular processes (Lim and Kaldis 2013). Cyclin M interacts with CDK10, and the CDK10/Cyclin M complex mediates degradation of the oncoprotein and transcription factor ETS2 (Guen et al.. 2013). Loss of CDK10 appears to be a major determinant of resistence to endocrine therapy for breast cancer (Iorns et al.. 2008). In addition, CDK10 seems to act as a tumor suppressor in nasopharyngeal carcicoma and in gastric cancer (You et al.. 2018). Using a zebrafish model, CDK10 was found to participate in transcriptional complexes that play key roles during development (Guen et al.. 2017).
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human CDK10 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
0.5% Bovine Serum Albumin
- Peptide with sequence AEPDLECEQIRLK , from the N Terminus of the protein sequence according to NP_443714.3.
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- For research purposes only
- 12 months from date of despatch
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
|Application Name||Verified||Min Dilution||Max Dilution|
|Western Blotting||3 µg/ml||0.5 µg/ml|
- Western Blotting
- Goat anti Human CDK10 antibody detects a band of approximately 38 kDa in cell lysates.
|Description||Product Code||Applications||Pack Size||List Price||Your Price||Quantity|
|Rabbit anti Goat IgG (Fc):FITC||STAR122F||F||1 mg||Log in|
|List Price||Your Price|
|Description||Rabbit anti Goat IgG (Fc):FITC|
|Rabbit anti Goat IgG (Fc):HRP||STAR122P||C E WB||1 mg||Log in|
|List Price||Your Price|
|Description||Rabbit anti Goat IgG (Fc):HRP|
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