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C-Reactive Protein antibody

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Human C-Reactive Protein detected using Goat anti Human C-Reactive Protein (1707-0189G)

Goat anti Human C-Reactive Protein

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
C-Reactive Protein

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Product Code Applications Pack Size List Price Your Price Qty
1707-0189G
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E ID 1 ml
List Price Your Price

Goat anti Human C-reactive protein antibody recognizes human C-reactive protein (CRP), a calcium-binding acute phase reactant belonging to the pentraxin family which is secreted into the plasma by the liver, in response to cytokine stimulation.

In addition to binding to phosphocholine residues, CRP can bind to other autologous and extrinsic ligands on targets, including damaged cell membranes, ribonucleoprotein particles, apoptotic cells and constituents of micro-organisms, and may activate the classical complement pathway through C1q recognition, making CRP a factor in a variety of host defense mechanisms. Levels of plasma CRP are significantly increased during the acute phase response, tissue injury and infection and can be used diagnostically as a marker of inflammation, disease progress and risk assessment of cardiovascular disease.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human C-reactive protein were raised by repeated immunisations of goats with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09%Sodium Azide (NaN3)
Immunogen
Native human C-reactive protein.
Approx. Protein Concentrations
IgG concentration 5.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/1000
Immunodiffusion 1/30 1/200
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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References for C-Reactive Protein antibody

  1. Günter, G. et al. (2019) Smartphone biosensor for Salmonella and Amitriptyline
    Proc. SPIE 11028, Optical Sensors 2019, 110280R

Further Reading

  1. Pepys, M.B. & Hirschfield, G.M. (2003) C-reactive protein: a critical update.
    J Clin Invest. 111 (12): 1805-12.
  2. Clearfield, M.B. (2005) C-reactive protein: a new risk assessment tool for cardiovascular disease.
    J Am Osteopath Assoc. 105 (9): 409-16.

Synonyms
CRP
RRID
AB_2057775
UniProt
P02741
Entrez Gene
CRP
GO Terms
GO:0005515 protein binding
GO:0006953 acute-phase response
GO:0046872 metal ion binding
GO:0008228 opsonization
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0030169 low-density lipoprotein particle binding
GO:0033265 choline binding
GO:0051637 Gram-positive bacterial cell surface binding

1707-0189G

159963 1608 1801

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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