C-Reactive Protein antibody

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Goat anti Human C-Reactive Protein

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
1707-0189G E ID 1 ml
Goat anti Human C-reactive protein antibody recognizes human C-reactive protein (CRP), a calcium-binding acute phase reactant belonging to the pentraxin family which is secreted into the plasma by the liver, in response to cytokine stimulation.

In addition to binding to phosphocholine residues, CRP can bind to other autologous and extrinsic ligands on targets, including damaged cell membranes, ribonucleoprotein particles, apoptotic cells and constituents of micro-organisms, and may activate the classical complement pathway through C1q recognition, making CRP a factor in a variety of host defense mechanisms. Levels of plasma CRP are significantly increased during the acute phase response, tissue injury and infection and can be used diagnostically as a marker of inflammation, disease progress and risk assessment of cardiovascular disease.

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human C-reactive protein were raised by repeated immunisations of goats with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09%Sodium Azide (NaN3)
Immunogen
Native human C-reactive protein.
Approx. Protein Concentrations
IgG concentration 5.0mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P02741 Related reagents
Entrez Gene
CRP Related reagents
GO Terms
GO:0005515 protein binding
GO:0006953 acute-phase response
GO:0046872 metal ion binding
GO:0008228 opsonization
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0030169 low-density lipoprotein particle binding
GO:0033265 choline binding
GO:0051637 Gram-positive bacterial cell surface binding
Regulatory
For research purposes only

Applications of C-Reactive Protein antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/1000
Immunodiffusion 1/30 1/200
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Rabbit anti Goat IgG (Fc):FITC STAR122F 1 mg F
Rabbit anti Goat IgG (Fc):HRP STAR122P 1 mg C E WB

Product Specific References

Further Reading

  1. Pepys, M.B. & Hirschfield, G.M. (2003) C-reactive protein: a critical update.
    J Clin Invest. 111 (12): 1805-12.
  2. Clearfield, M.B. (2005) C-reactive protein: a new risk assessment tool for cardiovascular disease.
    J Am Osteopath Assoc. 105 (9): 409-16.