Apolipoprotein E antibody

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Rabbit anti Apolipoprotein E

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified

Product Code	Applications	Pack Size	Your Price	List Price	Quantity
VPA00665 Datasheet	WB SDS	100 µl	Log in		Get Quote

Summary
Secondary Antibodies

Rabbit anti Human apolipoprotein E antibody recognizes apolipoprotein E, also known as apolipoprotein E3, APOE, APO-E, or LPG.

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants (provided by RefSeq, Jul 2008).

Rabbit anti Human apolipoprotein E antibody detects a band of 35 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species: Human
Western Blotting: Rabbit anti apolipoprotein E detects a band of approximately 35 kDa in HepG2 cell lysates
Product Form: Purified IgG - liquid
Preparation: Rabbit polyclonal antibody purified by affinity chromatography
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.01% Thiomersal
1% Bovine Serum Albumin
<50% Glycerol
Immunogen: Carrier-protein conjugated synthetic peptide encompassing part of the C terminal region of human apolipoprotein E

Storage Information

Storage: Store undiluted at -20^oC, avoiding repeated freeze thaw cycles.
Guarantee: 12 months from date of despatch

More Information

UniProt: P02649
Entrez Gene: APOE
GO Terms: GO:0000302 response to reactive oxygen species; GO:0001540 beta-amyloid binding; GO:0001937 negative regulation of endothelial cell proliferation; GO:0007010 cytoskeleton organization; GO:0005543 phospholipid binding; GO:0006641 triglyceride metabolic process; GO:0006898 receptor-mediated endocytosis; GO:0006916 anti-apoptosis; GO:0006917 induction of apoptosis; GO:0007186 G-protein coupled receptor protein signaling pathway; GO:0007263 nitric oxide mediated signal transduction; GO:0007271 synaptic transmission, cholinergic; GO:0008201 heparin binding; GO:0008219 cell death; GO:0010544 negative regulation of platelet activation; GO:0010873 positive regulation of cholesterol esterification; GO:0010875 positive regulation of cholesterol efflux; GO:0016209 antioxidant activity; GO:0019934 cGMP-mediated signaling; GO:0030425 dendrite; GO:0030516 regulation of axon extension; GO:0030828 positive regulation of cGMP biosynthetic process; GO:0032488 Cdc42 protein signal transduction; GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process; GO:0033344 cholesterol efflux; GO:0033700 phospholipid efflux; GO:0034361 very-low-density lipoprotein particle; GO:0034362 low-density lipoprotein particle; GO:0034363 intermediate-density lipoprotein particle; GO:0034364 high-density lipoprotein particle; GO:0034372 very-low-density lipoprotein particle remodeling; GO:0034375 high-density lipoprotein particle remodeling; GO:0034380 high-density lipoprotein particle assembly; GO:0034382 chylomicron remnant clearance; GO:0034384 high-density lipoprotein particle clearance; GO:0034447 very-low-density lipoprotein particle clearance; GO:0046911 metal chelating activity; GO:0042627 chylomicron; GO:0042632 cholesterol homeostasis; GO:0042803 protein homodimerization activity; GO:0043025 neuronal cell body; GO:0043407 negative regulation of MAP kinase activity; GO:0043537 negative regulation of blood vessel endothelial cell migration; GO:0043691 reverse cholesterol transport; GO:0045541 negative regulation of cholesterol biosynthetic process; GO:0046907 intracellular transport; GO:0046982 protein heterodimerization activity; GO:0048156 tau protein binding; GO:0048168 regulation of neuronal synaptic plasticity; GO:0050728 negative regulation of inflammatory response; GO:0070326 very-low-density lipoprotein particle receptor binding; GO:0050750 low-density lipoprotein particle receptor binding; GO:0051000 positive regulation of nitric-oxide synthase activity; GO:0051044 positive regulation of membrane protein ectodomain proteolysis; GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory: For research purposes only

Applications of Apolipoprotein E antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description	Product Code	Applications	Pack Size	Your Price	List Price	Quantity
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in		Get Quote

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