IL-1 Beta antibody
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Rabbit anti Chicken Interleukin-1 beta:Preservative Free
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- IL-1 Beta
Antibody Quality and Performance Guarantee
| Rabbit anti Chicken interleukin-1 beta antibody recognizes chicken Interleukin 1 beta (chIL-1beta), which shares
homology with mammalian IL-1beta. IL-1 is a major regulator in both innate and adaptive immune responses, plays an important role in the regulation of acute inflammation and has also been implicated in many other processes, including both fever and fibrinogen induction. The previous names by which IL-1 has been known includes lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor, reflecting its widespread cell expression. Chicken models indicate physiological similarities between chIL-1beta and mammalian IL-1beta in relation to its neural distribution and several factors have been shown to induce chIL-1beta secretion, including protein kinase C (PKC), Calmodulin-dependent protein kinase, lipopolysaccharide, phorbol esters, calcium and silica. Rabbit anti Chicken interleukin-1 beta antibody (AHP941Z) neutralizes chicken IL-1 beta (Gyorfy et al. 2003). |
- Target Species
- Chicken
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to chicken Interleukin-1β were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography on protein G
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Recombinant chicken IL-1β
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
||
| Functional Assays | |
||
| Western Blotting | |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Western Blotting
- AHP941Z detects a band of approximately 29kDa in HD-11 cell lysates transfected with chIL-1.
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References for IL-1 Beta antibody
-
Gyorfy, Z. et al. (2003) Truncated chicken interleukin-1beta with increased biologic activity.
J Interferon Cytokine Res. 23 (5): 223-8. -
De Boever, S. et al. (2010) Flow cytometric differentiation of avian leukocytes and analysis of their intracellular cytokine expression.
Avian Pathol. 39: 41-6.
Further Reading
-
Bombara, C.J. & TaylorRl, J.r. (1991) Signal transduction events in chicken interleukin-1 production.
Poult Sci. 70 (6): 1372-80. -
Weining, K.C. et al. (1998) A chicken homolog of mammalian interleukin-1 beta: cDNA cloning and purification of active recombinant protein.
Eur J Biochem. 258 (3): 994-1000. -
Staeheli, P. et al. (2001) Cytokines of birds: conserved functions--a largely different look.
J Interferon Cytokine Res. 21 (12): 993-1010.
AHP941Z
151927
158289
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