Interleukin-1 (IL-1) is a pro-inflammatory cytokine secreted by many different cell types which acts upon a wide range of target cells, resulting in a diverse range of effects. The biological properties of IL-1 include the induction of B cell proliferation, stimulation of T cell proliferation in conjunction with IL-2 and the production of collagenase and prostaglandin by fibroblasts. IL-1 is also responsible for triggering the acute-phase response in the liver, and is involved in both cytokine network and vascular endothelium activation.
PAP002 induces corticosterone secretion in vivo, see Weining, K.C. et al. for details. PAP002 is also the immunogen used to produce Bio-Rad chicken IL-1beta antibody product code AHP941Z.
Purified His-tagged recombinant protein expressed in E.coli - liquid
Recombinant protein prepared from E.coli
>85% by Ni chelate Chromatography
Approx. Protein Concentrations
Protein Molecular Weight
Reagents In The Kit
Preparing The Antibody
Phosphate buffered saline
Store at -20oC only. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
3 months from date of despatch.
For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
In vitro Assay
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.