Serotonin antibody | YC5/45
|Rat anti serotonin antibody, clone YC5/45 recognizes serotonin and does not cross react with 5-hydroxyindolacetic acid, GABA, noradrenaline, 5-hydroxytryptophan, carnosine or melatonin.
Serotonin, also known as 5-hydroxytryptamine or 5-HT is a biochemical messenger and neurotransmitter synthesized from L-tryptophan. Serotonin has a range of functions, including regulation of gastric motility, and may be related to some psychiatric disorders including schizophrenia and depression. Serotonin is widely distributed in the central and peripheral nervous system, and also in some non-neural tissues such as platelets.
Serotonin appears widely conserved and Rat anti serotonin antibody, clone YC5/45 has been used successfully to demonstrate serotonin immunoreactivity using immunohistochemistry in many diverse groups including primates (Vanoli et al. 2013), rodents (Hosoda et al. 1984), prototherian mammals, avians and reptiles (Adamson and Campbell 1988), teleosts (Takeda et al. 2014) through to invertebrates including hirudinids (Masuda-Nakagawa et al. 1990) and gastropods (Osborne and Dockray 1982).
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Human Rat Goldfish Cat Chicken Marine file snake Helix aspersa Hirudo medicinalis
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Tissue Culture Supernatant - liquid
- Preservative Stabilisers
- Serotonin conjugated to bovine serum albumin.
- Fusion Partners
- Spleen cells from immunised COB wistar rats were fused with cells of the Y3-Ag-1.2.3 rat myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen 1|
- 1Formaldehyde fixation is recommended.
References for Serotonin antibody
Consolazione, A. et al. (1981) Immunocytochemical detection of serotonin with monoclonal antibodies.
J Histochem Cytochem. 29: 1425-30.
Milstein, C. et al. (1983) The discrepancy between the cross-reactivity of a monoclonal antibody to serotonin and its immunohistochemical specificity.
Mol Immunol. 20 (1): 113-23.
Suárez-Quian, C.A. (1987) The distribution of four lysosomal integral membrane proteins (LIMPs) in rat basophilic leukemia cells.
Tissue Cell. 19: 495-504.
La Rosa, S. et al. (2011) Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms.
Hum Pathol. 42: 1373-84.
Takeda, A. et al. (2015) Axonal regeneration through the fibrous scar in lesioned goldfish spinal cord.
Neuroscience. 284: 134-52.
Cuello, A.C. et al. (1982) Immunocytochemistry with internally labeled monoclonal antibodies.
Proc Natl Acad Sci U S A. 79: 665-9.
Gil-Loyzaga, P. et al. (1997) Serotonergic innervation of the organ of Corti of the cat cochlea.
Neuroreport. 8: 3519-22.
Osborne, N.N. (1982) Uptake, localization and release of serotonin in the chick retina.
J Physiol. 331: 469-79.
View The Latest Product References
Vanoli, A. et al. (2013) Histologic changes in type A chronic atrophic gastritis indicating increased risk of neuroendocrine tumor development: the predictive role of dysplastic and severely hyperplastic enterochromaffin-like cell lesions.
Hum Pathol. 44: 1827-37.
Dainese, E. et al. (2013) Linear and micronodular neuroendocrine cell hyperplasia in an ovarian mucinous cystadenoma.
Pathol Res Pract. 209: 670-3.
Solcia, E. et al. (1990) Gastric argyrophil carcinoidosis in patients with Zollinger-Ellison syndrome due to type 1 multiple endocrine neoplasia. A newly recognized association.
Am J Surg Pathol. 14 (6): 503-13.
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