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Secukinumab antibody | AbD36949

Human anti Secukinumab (Drug/Target Complex)

Product Type
Monoclonal Antibody
HuCAL Fab monovalent

Product Code Applications Pack Size List Price Your Price Qty
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 0.1 mg loader
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Human Anti-Secukinumab (Drug/Target Complex) Antibody, clone AbD36949 specifically recognizes the human monoclonal antibody drug secukinumab when in complex with its target, interleukin 17A (IL-17A). The antibody does not recognize free secukinumab or unbound IL-17A. It can be used to measure levels of secukinumab or its biosimilars in patient samples.

Clone AbD36949 is a monovalent Fab format antibody that can be used to develop a pharmacokinetic (PK) antigen capture assay to measure free secukinumab that has been captured via immobilized IL-17A.

Secukinumab (Cosentyx) is a human IgG1/kappa antibody generated using transgenic mouse technology. It has been approved for the treatment of plaque psoriasis, ankylosing spondylitis, psoriatic arthritis and non-radiographic axial spondyloarthritis. Secukinumab inhibits interleukin 17A (IL-17A) produced mainly by inflammatory T helper 17 cells (Lubrano and Perrotta 2016).

View a summary of all anti- secukinumab antibodies
20th Anniversary

Product Form
A monovalent human recombinant Fab (kappa light chain) selected from the HuCAL phage display library, expressed in E. coli.The antibody is tagged with a DYKDDDDK tag and a HIS-tag (HHHHHH) at the C-terminus of the antibody heavy chain. This antibody is supplied as a liquid.
Metal chelate affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Secukinumab/IL-17A complex
The intrinsic affinity of the monovalent form of Human anti Secukinumab antibody, clone AbD36949 is KD = 7 nM as measured by real time, label free molecular interaction analysis on immobilized hIL-17A/secukinumab complex.
Approx. Protein Concentrations
Antibody concentration 0.5 mg/ml
For research purposes only
12 months from date of despatch
This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See for details.
His-tag is a registered trademark of EMD Biosciences.
Cosentyx is a trademark of Novartis.
Licensed Use
For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Technical Advice
Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
Human anti Secukinumab antibody, clone AbD36949 is suitable for use as a detection antibody for Secukinumab captured via immobilized hIL-17A.
Protocol: PK antigen capture ELISA.

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Further Reading

  1. Lubrano, E. & Perrotta, F.M. (2016) Secukinumab for ankylosing spondylitis and psoriatic arthritis.
    Ther Clin Risk Manag. 12: 1587-92.




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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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