Uvrag antibody | AB05/4B1

Mouse anti Uvrag

Product Type
PrecisionAb Monoclonal
Clone
AB05/4B1
Isotype
IgG2b
Format
Purified
Specificity
Uvrag

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VMA00974
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Mouse anti UVRAG antibody recognizes UV radiation resistance-associated gene protein, also known as p63. UVRAG is a tumor suppressor protein which surveys DNA integrity in response to DNA damage. It is a promoter of autophagy which plays an important role in maintaining energy homeostasis. UVRAG is important during the tanning response to UV light, downstream of the cAMP signaling pathway. It mediates biogenesis of melanosomes via its interaction with BLOC-1 (Yang et al. 2018). This process provides a first line of defence against development of skin cancer. Abnormally low levels of UVRAG contribute to the development of many types of cancer (Li et al. 2019). Accordingly, low UVRAG expression in patients with melanoma is associated with worse clinical outcome (Yang et al. 2016). Polymorphisms in the gene encoding UVRAG are associated with vitiligo, a disorder affecting melanocytes and causing loss of skin pigmentation (Rashighi and Harris 2017). PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti UVRAG detects a band of approximately 94 kDa in Raji cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 200-699 of human UVRAG
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/500 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q9P2Y5
Entrez Gene
UVRAG
GO Terms
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0006281 DNA repair
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