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STAT5 antibody | OTI9F7

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Anti STAT5 Antibody, clone OTI9F7 (PrecisionAb Monoclonal Antibody) thumbnail image 1
Anti STAT5 Antibody, clone OTI9F7 (PrecisionAb Monoclonal Antibody) gallery image 1
Western blot analysis of whole cell lysates probed with STAT5 antibody followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 9 second exposure. Arrow points to STAT5 (molecular weight 90 kDa)

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WB

Mouse anti STAT5

Product Type
PrecisionAb Monoclonal
Clone
OTI9F7
Isotype
IgG1
Format
Purified
Specificity
STAT5

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Product Code Applications Pack Size List Price Your Price Qty
VMA00711
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 100 µl loader
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loader

Mouse anti Human STAT5 antibody recognizes the signal transducer and activator of transcription 5A/5B.

Signal transducer and activator of transcription 5 (STAT5) refers to two highly related proteins, STAT5A and STAT5B, which are part of the STAT family of transcription factors. In response to cytokines (IL2, IL4) and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. It has been shown that STAT5 is involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Though STAT5A and STAT5B are encoded by separate genes, the proteins are 90% identical at the amino acid level. Aberrant STAT5 activity has been shown to be closely connected to a wide range of human cancers (provided by RefSeq, Jul 2008).

Mouse anti Human STAT5 detects a band of 90 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.		 PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti STAT5 detects a band of approximately 90 kDa in K562 cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
<50% Glycerol
Immunogen
Full length recombinant human STAT5A produced in HEK293T cells
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description Product Code Applications Pack Size List Price Your Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
List Price Your Price
loader
Description Goat anti Mouse IgG (H/L):HRP

UniProt
P42229
P51692
Entrez Gene
STAT5A
STAT5B
GO Terms
GO:0005515 protein binding
GO:0000255 allantoin metabolic process
GO:0005509 calcium ion binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005829 cytosol
GO:0005654 nucleoplasm
GO:0006101 citrate metabolic process
GO:0006103 2-oxoglutarate metabolic process
GO:0006105 succinate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006549 isoleucine metabolic process
GO:0006573 valine metabolic process
GO:0006600 creatine metabolic process
GO:0006631 fatty acid metabolic process
GO:0019530 taurine metabolic process
GO:0046449 creatinine metabolic process
GO:0032355 response to estradiol stimulus
GO:0035259 glucocorticoid receptor binding
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway

VMA00711

171011

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