Somatostatin antibody | YC7

Rat anti Human Somatostatin

Product Type
Monoclonal Antibody
Clone
YC7
Isotype
IgG2b
Specificity
Somatostatin

Product Code Applications Pack Size List Price Your Price Qty
8330-0009
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SDS Safety Datasheet SDS
C P 0.2 ml loader
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loader
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Rat anti Human Somatostatin antibody, clone YC7 recognizes somatostatin, a hormone involved in endocrine system regulation through interactions with pituitary growth hormone, thyroid stimulating hormone, and a number of hormones of the gastrointestinal tract. Somatostatin has active 14 amino acid and 28 amino acid forms, produced by alternate cleavage of the gene product.

This antibody does not cross react with enkephalins, other endorphins, substance P, or CGRP. It partially cross reacts with somatostatin fragments.

The epitope recognized by this antibody lies within the 1-14 amino acid sequence of cyclic somatostatin.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
Guinea Pig
Pig
Mouse
Zebrafish
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Tissue Culture Supernatant - liquid
Preservative Stabilisers
0.05% Thiomersal
Immunogen
Somatostatin conjugated to thyroglobulin.
Fusion Partners
Spleen cells from rats immunised with somatostatin conjugated to thyroglobulin were fused with a rat myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen
Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

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References for Somatostatin antibody

  1. Pidsudko, Z. et al. (2004) Distribution and chemical coding of neurons in intramural ganglia of the porcine urinary bladder trigone.
    Folia Histochem Cytobiol. 42: 3-11.
  2. Van Nassauw, L. et al. (2002) Neurochemical identification of enteric neurons expressing P2X(3) receptors in the guinea-pig ileum.
    Histochem Cell Biol. 118 (3): 193-203.
  3. Geuens, E. et al. (2003) A globin in the nucleus!
    J Biol Chem. 278: 30417-20.
  4. Kaleczyc, J. et al. (2002) Distribution, immunohistochemical characteristics and nerve pathways of primary sensory neurons supplying the porcine vas deferens.
    Cell Tissue Res. 310: 9-17.
  5. Pidsudko, Z. (2014) Immunohistochemical characteristics and distribution of sensory dorsal root Ganglia neurons supplying the urinary bladder in the male pig.
    J Mol Neurosci. 52 (1): 71-81.
  6. Hens, J. et al. (2001) Morphological and neurochemical identification of enteric neurones with mucosal projections in the human small intestine.
    J Neurochem. 76: 464-71.
  7. Hens, J. et al. (2000) Mucosal projections of enteric neurons in the porcine small intestine.
    J Comp Neurol. 421: 429-36.
  8. Rychlik, A. et al. (2002) Diarrhea-Induced Changes in Chemical Phenotypes of Enteric Structures in the Pig are not Sufficient to Discriminate between the Viral and Bacterial Etiology of the Disease.
    Bull Vet Inst Pulawy 46, 187-96.
  9. View The Latest Product References
  10. Podlasz, P. et al. (2016) Galanin regulates blood glucose level in the zebrafish: a morphological and functional study.
    Histochem Cell Biol. 145 (1): 105-17.
  11. Kaleczyc, J. et al. (2007) The distribution and chemical coding of intramural neurons supplying the porcine stomach - the study on normal pigs and on animals suffering from swine dysentery.
    Anat Histol Embryol. 36 (3): 186-93.
  12. Pidsudko, Z. et al. (2008) Distribution and chemical coding of intramural neurons in the porcine ileum during proliferative enteropathy.
    J Comp Pathol. 138 (1): 23-31.
  13. Zacharko-Siembida, A. et al. (2017) An Immunohistochemical Study of Cocaine- and Amphetamine-Regulated Transcript (Cart) Expression in the Pterygopalatine Ganglion of the Pig.
    Acta Veterinaria. 67 (3): 397-408.
  14. Palus, K. et al. (2018) Neurochemical characteristics of calbindin-like immunoreactive coeliac-cranial mesenteric ganglion complex (CCMG) neurons supplying the pre-pyloric region of the porcine stomach
    Tissue and Cell. 50: 8-14.

Further Reading

  1. Milstein, C. & Cuello, A.C. (1983) Hybrid hybridomas and their use in immunohistochemistry.
    Nature. 305: 537-40.

RRID
AB_2195908
UniProt
P61278
Entrez Gene
SST
GO Terms
GO:0005179 hormone activity
GO:0005615 extracellular space
GO:0007186 G-protein coupled receptor protein signaling pathway
GO:0007268 synaptic transmission
GO:0007584 response to nutrient
GO:0007586 digestion
GO:0008285 negative regulation of cell proliferation
GO:0008628 induction of apoptosis by hormones
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