Progesterone Receptor antibody | UMAB137

Mouse anti Progesterone Receptor

Product Type
PrecisionAb Monoclonal
Clone
UMAB137
Isotype
IgG2a
Format
Purified
Specificity
Progesterone Receptor

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VMA00390
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Mouse anti Human progesterone receptor antibody, clone UMAB137 recognizes the progesterone receptor, also known as PGR and nuclear receptor subfamily 3 group C member 3.

Encoded by the PGR gene, the progesterone receptor is a member of the steroid receptor superfamily. This protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PGR uses two distinct promoters and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap (provided by RefSeq, Jan 2011).

Mouse anti Human progesterone receptor antibody detects bands of 90 and 118 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti progesterone receptor detects bands of approximately 90 and 118 kDa in MCF7 cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Recombinant protein fragment corresponding to aa 1-298 of human progesterone receptor (NP_000917) produced in E.coli
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P06401
Entrez Gene
PGR
GO Terms
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0005102 receptor binding
GO:0005496 steroid binding
GO:0005737 cytoplasm
GO:0005654 nucleoplasm
GO:0007267 cell-cell signaling
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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