Rabbit anti Human mTOR antibody recognizes mammalian/mechanistic target of rapamycin (mTOR), also known as FRAP, RAFT1. mTOR is a serine/threonine protein kinase belonging to the PI3K-related kinse (PIKK) family. mTOR forms two distinct multiprotein complexes named mTORC1 and mTORC2, which play key roles in regulatory processes of cells (Xie et al. 2016). mTOR regulates cell growth and metabolism in response to environmental cues and cell stress, including nutrient starvation, growth factor deprivation and hypoxia (Lamm et al. 2019). The mTOR signaling pathway plays a role in cancer cell proliferation, cell cycle and apoptosis. mTOR dysregulation is linked to tumorigenesis, and is associated with a poor prognosis (Wang et al. 2018). mTORC1 hyperactivation is estimated to occur in up to 70% of human tumors, and mTOR has been suggested as a potential target for anti-cancer therapy.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to Human serine/threonine-protein kinase mTOR
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use
- 12 months from date of despatch
- Entrez Gene
- GO Terms
protein serine/threonine kinase activity
mitochondrial outer membrane
endoplasmic reticulum membrane
phosphatidylinositol 3-kinase complex
response to nutrient
insulin receptor signaling pathway
protein catabolic process
T cell costimulation
TOR signaling cascade
response to amino acid stimulus
nerve growth factor receptor signaling pathway
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of mTOR antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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