CD2 antibody | LT2
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F ResetMouse anti Human CD2:Biotin
- Product Type
- Monoclonal Antibody
- Clone
- LT2
- Isotype
- IgG2b
- Specificity
- CD2
Mouse anti Human CD2 antibody, clone LT2 recognizes human CD2, a single chain transmembrane glycoprotein of 50 kDa, expressed by T cells, NK cells and thymocytes. CD2 is a receptor for CD58 (LFA-3), and is important in mediating the interaction between T cells and target cells or antigen presenting cells. Mouse anti Human CD2 antibody, clone LT2 inhibits NK cell mediated cytotoxicity, and ConA and PHA mediated blast transformation. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rhesus Monkey Chimpanzee Cynomolgus monkey - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG conjugated to biotin - liquid.
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
1% bovine serum albumin - Immunogen
- Normal human peripheral blood lymphocytes.
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml
- Fusion Partners
- Spleen cells from immunized BALB/c mice were fused with cells of the mouse X63.653 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | Neat |
- Flow Cytometry
- Use 10Μl of the suggested working dilution to label 106 cells or 100μl of whole blood using the lysed whole blood labeling method
How to Use the Spectraviewer
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Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Human Seroblock | BUF070A | F | 50 Test | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Human Seroblock | ||||||
Human Seroblock | BUF070B | F | 200 Test | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Human Seroblock |
References for CD2 antibody
-
Lin, C.W. et al. (2005) CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features.
Blood. 106 (10): 3567-74. -
Kap, Y.S. et al. (2009) A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.
J Histochem Cytochem. 57: 1159-67. -
Bruger, A.M. et al. (2020) Protocol to assess the suppression of T-cell proliferation by human MDSC.
Methods Enzymol. 632: 155-92.
Further Reading
-
Moingeon, P. et al. (1989) The structural biology of CD2.
Immunol Rev. 111: 111-44. -
Beyers, A.D. et al. (1989) Activation of T lymphocytes via monoclonal antibodies against rat cell surface antigens with particular reference to CD2 antigen.
Immunol Rev. 111: 59-77.
- Synonyms
- LFA-2
- RRID
- AB_323385
- UniProt
- P06729
- Entrez Gene
- CD2
- GO Terms
- GO:0001766 membrane raft polarization
- GO:0007596 blood coagulation
- GO:0004872 receptor activity
- GO:0005887 integral to plasma membrane
- GO:0006917 induction of apoptosis
- GO:0007166 cell surface receptor linked signaling pathway
- GO:0016337 cell-cell adhesion
- GO:0030101 natural killer cell activation
- GO:0030887 positive regulation of myeloid dendritic cell activation
- View More GO Terms
- GO:0042110 T cell activation
- GO:0045580 regulation of T cell differentiation
- GO:0050900 leukocyte migration
MCA1194B
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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