AXL Receptor Tyrosine Kinase antibody | 7E10

Mouse anti AXL Receptor Tyrosine Kinase

Product Type
PrecisionAb Monoclonal
Clone
7E10
Isotype
IgG1
Format
Purified
Specificity
AXL Receptor Tyrosine Kinase

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VMA00320
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Mouse anti Human AXL receptor tyrosine kinase antibody recognizes the AXL oncogene, also known as AXL transforming sequence/gene and tyrosine-protein kinase receptor UFO.

Encoded by the AXL gene, the AXL oncogene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. It possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). AXL may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of AXL (provided by RefSeq, Jul 2013).

Mouse anti Human AXL receptor tyrosine kinase antibody detects a band of 138 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti AXL receptor tyrosine kinase detects a band of approximately 138 kDa in HeLa cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody prepared by affinity chromatography on Protein G from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
Purified recombinant extracellular fragment of human AXL receptor tyrosine kinase fused with hIgGFc tag expressed in the HEK293 cell line
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml.
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P30530
Entrez Gene
AXL
GO Terms
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005887 integral to plasma membrane
GO:0005524 ATP binding
GO:0006468 protein phosphorylation