CD11c antibody | BAQ153A

Mouse anti Bovine CD11c

Product Type
Monoclonal Antibody
Clone
BAQ153A
Isotype
IgM
Specificity
CD11c

Product Code Applications Pack Size List Price Your Price Qty
MCA6084
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F IC 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Bovine CD11c, clone BAQ153A, recognizes bovine CD11c also known as integrin alpha X. CD11c is a receptor for fibrinogen recognizing the G-P-R motif in fibrinogen. It is involved in the cell to cell interaction during inflammatory responses. In addition, it has an important function in adhesion and chemotaxis in monocytes, macrophages and dendritic cells (DCs).

In cattle, CD11c+ DCs are a source of the anti-inflammatory cytokine IL-10 during infection by the highly pathogenic foot-and-mouth disease virus (FMDV). IL-10 may be responsible for the reduction in the antigen processing ability of DCs during FMDV infection (Sei et al. 2016). Clone BAQ153A reacts with bovine CD11c+ macrophages, DCs and some lymphocytes as shown by IHC (Palmer et al. 2011) and flow cytometry (Sei et al. 2016).

Target Species
Bovine
Species Cross-Reactivity
Target SpeciesCross Reactivity
Goat
Sheep
Bison
Water Buffalo
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Concentrated tissue culture supernatant - liquid
Preparation
Concentrated tissue culture supernatant clarified by filtration through a 0.2 micrometer filter
Buffer Solution
Serum free tissue culture medium containing proprietary protein free supplement
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Cells from multiple species
Approx. Protein Concentrations
Ig concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at +4oC. DO NOT FREEZE.
Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry Neat 1/10
Functional Assays
Immunocytochemistry
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul of the suggested working dilution to label 106 cells in 100ul

Description Product Code Applications Pack Size List Price Your Price Quantity
Mouse anti Bovine CD14 MCA6085 F 0.1 mg loader
List Price Your Price
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Description Mouse anti Bovine CD14

References for CD11c antibody

  1. Srsen S. et al. (1989) Jacob's syndrome (2 case reports).
    Cesk Pediatr. 44 (7): 420-2.
  2. Naessens, J. & Hopkins, J. (1996) Introduction and summary of workshop findings
    Veterinary Immunology and Immunopathology. 52 (4): 213-35.
  3. Jeyaseelan S. et al. (2001) Mannheimia haemolytica leukotoxin activates a nonreceptor tyrosine kinase signaling cascade in bovine leukocytes, which induces biological effects.
    Infect Immun. 69 (10): 6131-9.
  4. Elnaggar, M.M. et al. (2016) Characterization and use of new monoclonal antibodies to CD11c, CD14, and CD163 to analyze the phenotypic complexity of ruminant monocyte subsets.
    Vet Immunol Immunopathol. 178: 57-63.
  5. Liu, J. et al. (2020) Theileria annulata. transformation altered cell surface molecules expression and endocytic function of monocyte-derived dendritic cells.
    Ticks Tick Borne Dis. 11 (3): 101365.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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