CD11c antibody | BAQ153A

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Mouse anti Bovine CD11c

Product Type
Monoclonal Antibody
Clone
BAQ153A
Isotype
IgM
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
MCA6084 F IC 0.1 mg
Mouse anti Bovine CD11c, clone BAQ153A, recognizes bovine CD11c also known as integrin alpha X. CD11c is a receptor for fibrinogen recognizing the G-P-R motif in fibrinogen. It is involved in the cell to cell interaction during inflammatory responses. In addition, it has an important function in adhesion and chemotaxis in monocytes, macrophages and dendritic cells (DCs).

In cattle, CD11c+ DCs are a source of the anti-inflammatory cytokine IL-10 during infection by the highly pathogenic foot-and-mouth disease virus (FMDV). IL-10 may be responsible for the reduction in the antigen processing ability of DCs during FMDV infection (Sei et al. 2016). Clone BAQ153A reacts with bovine CD11c+ macrophages, DCs and some lymphocytes as shown by IHC (Palmer et al. 2011) and flow cytometry (Sei et al. 2016).

Product Details

Target Species
Bovine
Species Cross-Reactivity
Target SpeciesCross Reactivity
Goat
Sheep
Bison
Water Buffalo
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Concentrated tissue culture supernatant - liquid
Preparation
Concentrated tissue culture supernatant clarified by filtration through a 0.2 micrometer filter
Buffer Solution
Serum free tissue culture medium containing proprietary protein free supplement
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Cells from multiple species
Approx. Protein Concentrations
Ig concentration 1.0 mg/ml

Storage Information

Storage
Store at +4oC. DO NOT FREEZE.
Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
12 months from date of despatch

More Information

Regulatory
For research purposes only

Applications of CD11c antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry Neat 1/10
Functional Assays
Immunocytochemistry
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul of the suggested working dilution to label 106 cells in 100ul

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Goat anti Mouse IgM:RPE STAR86PE 0.5 ml F

Useful Reagents Available

Description Product Code Pack Size Applications List Price Quantity
Mouse anti Bovine CD14 MCA6085 0.1 mg F

Product Specific References

References for CD11c antibody

  1. Srsen S. et al. (1989) Jacob's syndrome (2 case reports).
    Cesk Pediatr. 44 (7): 420-2.
  2. Naessens, J. & Hopkins, J. (1996) Introduction and summary of workshop findings
    Veterinary Immunology and Immunopathology. 52 (4): 213-35.
  3. Jeyaseelan S. et al. (2001) Mannheimia haemolytica leukotoxin activates a nonreceptor tyrosine kinase signaling cascade in bovine leukocytes, which induces biological effects.
    Infect Immun. 69 (10): 6131-9.