Brentuximab Vedotin antibody | AbD39659ia
Human anti Brentuximab Vedotin
- Product Type
- Monoclonal Antibody
- Clone
- AbD39659ia
- Isotype
- IgG1
- Specificity
- Brentuximab Vedotin
Human Anti-Brentuximab vedotin Antibody, clone AbD39659ia is a paratope specific, inhibitory anti-idiotypic antibody that specifically recognizes the monoclonal antibody drug brentuximab, both alone and as the antibody drug conjugate (ADC), brentuximab vedotin. Clone AbD39659ia is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or reference standard in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 1.4 nM and is one of three antibodies with different affinities offered for ADA assays. Antibody HCA350 has affinity 6 nM and HCA351 has affinity 0.7 nM. Brentuximab vedotin (Adcetris) is a chimeric mouse/human IgG1 kappa ADC, approved by the FDA for the treatment of Hodgkin’s lymphoma (HL) and systemic anaplastic large cell lymphoma (ALCL). The brentuximab antibody selectively targets tumor cells expressing the cell membrane protein CD30, and delivers the conjugated toxin, monomethyl auristatin E (MMAE). Once inside the cell the MMAE is released from the antibody by proteolytic cleavage and disrupts the microtubule network inducing cell cycle arrest and apoptosis of the malignant cells, thereby preventing tumor growth and proliferation. View a summary of all brentuximab vedotin antibodies. |
- Product Form
- Human IgG1 antibody (kappa light chain) selected from the HuCAL phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Source
- HKB-11
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Brentuximab vedotin
- Affinity
- The intrinsic affinity of the monovalent form of Human anti Brentuximab Vedotin antibody, clone AbD39659ia is KD = 1.4 nM as measured by real time, label free molecular interaction analysis on immobilized Brentuximab Vedotin.
- Approx. Protein Concentrations
- Antibody concentration 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
Adcentris is a trademark of Seattle Genetics. - Licensed Use
- For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA |
- Technical Advice
- Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
- ELISA
- Human anti Brentuximab Vedotin antibody, clone AbD39659ia can be used as a surrogate positive control or calibrator in an anti-drug antibody assay.
Protocol: ADA bridging ELISA.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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Hispec Assay Diluent | BUF049A | E IY | 50 ml | Log in | |||
List Price | Your Price | ||||||
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Description | Hispec Assay Diluent | ||||||
Human anti Brentuximab Vedotin | HCA349 | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Brentuximab Vedotin | ||||||
Human anti Brentuximab Vedotin | HCA350 | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Brentuximab Vedotin | ||||||
Human anti Brentuximab Vedotin | HCA351 | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Brentuximab Vedotin | ||||||
LYNX Rapid HRP Antibody Conjugation Kit | LNK002P | CJ | 3 Conjugations For 400µg Antibody | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | LYNX Rapid HRP Antibody Conjugation Kit |
- Synonyms
- Adcetris
HCA352
161478If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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