|Specificity||Target Species||Host Species||Clone||Format||Pack Size||Applications||Product Code|
|AURORA-A KINASE||Human||Mouse||35C1||Purified||0.1 mg||IF, IP, WB||MCA2249|
|AURORA-A KINASE||Human||Mouse||35C1||Biotin||0.1 mg||IF, WB||MCA2249B|
|AURORA-B KINASE||Human||Rabbit||Purified||0.05mg||E, WB||AHP1261|
Cell cycle progression through mitosis and meiosis involves regulation by serine/threonine kinases from the Aurora family (1). A key member of the Aurora family is Aurora A Kinase (Aurora 2, murine serine/threonine Kinase 6 (STK6), human serine/threonine Kinase 15 (STK15)).
During interphase, Aurora A Kinase localises to the centrosome, which organizes microtubule assembly into a mitotic spindle. Aurora A Kinase regulates mitotic spindle assembly and stabilization through the recruitment of different proteins including Kinesin 5 and TACC 3 (2).
Aurora A Kinase expression is regulated by the tumor suppressor protein p53, which is found at the centrosome during mitosis. p53 binds and inhibits Aurora A Kinase activity (3). Choose from our selection of quality p53 Antibodies.
Aurora A Kinase also acts as an oncogene as it has been shown to transform cells in vitro (4). The role of Aurora A Kinase in cancer is thought to be due to its dysregulation. This leads to cells unable to complete mitosis, resulting in aneuploid cells, which are a trait of many tumors (5). As Aurora A Kinase is over-expressed in many tumors, including breast, colon, leukemia, ovarian and prostate (1), it is now a target for cancer therapy.
Current research in the pharmaceutical industry includes the development of Aurora A Kinase inhibitors as novel cancer treatments, some of which are already in clinical trials (6),(7). Our cell biology range has a selection of quality products dedicated to Oncoprotein and Tumour Suppressor Protein Research.
Our Aurora A Kinase Antibodies are suitable for immunohistochemistry of frozen tissue sections, immunofluorescence, immunoprecipitation and Western blotting. MCA2249 (Clone 35C1) is available in a choice of purified and biotin formats and also cross-reacts with mouse.
It specifically recognizes an epitope within the non-catalytic N-terminal domain of Aurora A Kinase and does not inhibit Aurora A Kinase activity (8). These quality antibodies are part of our extensive Cell Cycle Associated Reagents from the cell biology range. Visit the Cell Biology microsite for further details now.