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|Recombinant mouse interferon gamma is an E. coli-derived recombinant protein corresponding to full-length mature murine interferon gamma, a regulatory cytokine, which is produced by activated natural killer cells and certain T-lymphocytes.|
- Target Species
- Product Form
- Purified recombinant protein - lyophilized
- Reconstitute with 20ul water. For extended storage the addition of 0.1% BSA is recommended.
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution.
- Recombinant protein expressed in Escherichia coli
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Carrier Free
- >5 x 106 units/mg as determined by ability to inhibit the proliferation of murine WEHI-279 cells.
- >98% by SDS PAGE and HPLC
- Approx. Protein Concentrations
- Total protein concentration 1.0mg/ml after reconstitution
- Protein Molecular Weight
- 15.6kD (134 amino acid sequence)
- Endotoxin Level
- < 0.1 ng/ug
- For research purposes only
- Guaranteed for 3 months from the date of reconstitution or until the date of expiry, whichever comes first. Please see label for expiry date.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
|Application Name||Verified||Min Dilution||Max Dilution|
References for IFN Gamma
Zhang, H. et al. (2011) Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord.
J Neurosci. 31: 15894-903.
Wimmer, N. et al. (2012) Lymphotoxin β receptor activation on macrophages induces cross-tolerance to TLR4 and TLR9 ligands.
J Immunol. 188 (7): 3426-33.
Lam RS et al. (2016) Unprimed, M1 and M2 Macrophages Differentially Interact with Porphyromonas gingivalis.
PLoS One. 11 (7): e0158629.
Lestinova, T. et al. (2015) Phlebotomus papatasi exposure cross-protects mice against Leishmania major co-inoculated with Phlebotomus duboscqi salivary gland homogenate.
Acta Trop. 144: 9-18.
- Interferon Gamma
- Entrez Gene
- GO Terms
- GO:0005622 intracellular
- GO:0001781 neutrophil apoptosis
- GO:0042742 defense response to bacterium
- GO:0009615 response to virus
- GO:0005125 cytokine activity
- GO:0005133 interferon-gamma receptor binding
- GO:0005615 extracellular space
- GO:0006925 inflammatory cell apoptosis
- GO:0006955 immune response
- View More GO Terms
- GO:0019882 antigen processing and presentation
- GO:0030593 neutrophil chemotaxis
- GO:0030968 endoplasmic reticulum unfolded protein response
- GO:0031642 negative regulation of myelination
- GO:0032735 positive regulation of interleukin-12 production
- GO:0044130 negative regulation of growth of symbiont in host
- GO:0042102 positive regulation of T cell proliferation
- GO:0042832 defense response to protozoan
- GO:0045080 positive regulation of chemokine biosynthetic process
- GO:0045084 positive regulation of interleukin-12 biosynthetic process
- GO:0045348 positive regulation of MHC class II biosynthetic process
- GO:0045410 positive regulation of interleukin-6 biosynthetic process
- GO:0045429 positive regulation of nitric oxide biosynthetic process
- GO:0045893 positive regulation of transcription, DNA-dependent
- GO:0048304 positive regulation of isotype switching to IgG isotypes
- GO:0050718 positive regulation of interleukin-1 beta secretion
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