GluR1 (pSer831) antibody

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Rabbit anti GluR1 (pSer831)

Product Type: Polyclonal Antibody
Isotype: Polyclonal IgG

Product Code	Applications	Pack Size	Your Price	List Price	Quantity
AHP914 Datasheet	WB SDS	0.15 ml	Log in		Get Quote

Rabbit anti Rat GluR1 (pSer831) antibody recognizes glutamate receptor 1 (GluR1), also known as AMPA-selective glutamate receptor 1, GluR-A, GluR-K1 and glutamate receptor ionotropic , AMPA 1 (GluA1), when phosphorylated at serine 831.

GluR1, widely expressed throughout the nervous system is a component of AMPA receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid receptors), which play a key role at excitatory synapses.

Phosphorylation of Ser831 and Ser845 is reported to potentiate GluR1 function, suggesting a possible role in synaptic plasticity, learning and memory.

Product Details

Target Species

Rat

Species Cross-Reactivity

Target Species	Cross Reactivity
Mouse	Expected from Sequence
Dog	Expected from Sequence
Human	Expected from Sequence
Chicken	Expected from Sequence

N.B. Antibody reactivity and working conditions may vary between species.

Product Form

Purified IgG - liquid

Antiserum Preparation

Antisera to phosphorylated GluR1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by sequential affinity chromatography on phospho- and dephosphopeptide affinity columns.

Buffer Solution

10mM HEPES pH7.5

Preservative Stabilisers

0.09%	Sodium Azide
0.01%	Bovine Serum Albumin
50%	Glycerol

Immunogen

Synthetic phosphopeptide corresponding to amino acid sequence within GluR1 which includes the phosphorylated residue Ser831.

Storage Information

Storage: This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Guarantee: 12 months from date of despatch

More Information

UniProt: P19490
Entrez Gene: Gria1
GO Terms: GO:0001919 regulation of receptor recycling; GO:0001965 G-protein alpha-subunit binding; GO:0005829 cytosol; GO:0004970 ionotropic glutamate receptor activity; GO:0051018 protein kinase A binding; GO:0005234 extracellular-glutamate-gated ion channel activity; GO:0005769 early endosome; GO:0005789 endoplasmic reticulum membrane; GO:0007616 long-term memory; GO:0008179 adenylate cyclase binding; GO:0008328 ionotropic glutamate receptor complex; GO:0042493 response to drug; GO:0010226 response to lithium ion; GO:0014069 postsynaptic density; GO:0046685 response to arsenic-containing substance; GO:0019228 regulation of action potential in neuron; GO:0019717 synaptosome; GO:0019901 protein kinase binding; GO:0021510 spinal cord development; GO:0030054 cell junction; GO:0030165 PDZ domain binding; GO:0031267 small GTPase binding; GO:0031489 myosin V binding; GO:0031594 neuromuscular junction; GO:0031623 receptor internalization; GO:0031681 G-protein beta-subunit binding; GO:0031698 beta-2 adrenergic receptor binding; GO:0032279 asymmetric synapse; GO:0032355 response to estradiol stimulus; GO:0035249 synaptic transmission, glutamatergic; GO:0042220 response to cocaine; GO:0042803 protein homodimerization activity; GO:0043025 neuronal cell body; GO:0043197 dendritic spine; GO:0043198 dendritic shaft; GO:0045211 postsynaptic membrane; GO:0045838 positive regulation of membrane potential; GO:0048167 regulation of synaptic plasticity; GO:0050806 positive regulation of synaptic transmission; GO:0051602 response to electrical stimulus; GO:0060992 response to fungicide; GO:0071230 cellular response to amino acid stimulus; GO:0071359 cellular response to dsRNA; GO:0071363 cellular response to growth factor stimulus; GO:0071375 cellular response to peptide hormone stimulus; GO:0071407 cellular response to organic cyclic compound; GO:0071445 cellular response to protein stimulus
Regulatory: For research purposes only

Applications of GluR1 (pSer831) antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

Western Blotting: AHP914 detects a band of approximately 100 kDa in rat brain lysates.

Secondary Antibodies Available

Description	Product Code	Applications	Pack Size	Your Price	Quantity
Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E WB	1 mg	Log in	Get Quote
Goat anti Rabbit IgG (Fc):FITC	STAR121F	F	1 mg	Log in	Get Quote
Goat anti Rabbit IgG (Fc):HRP	STAR121P	E WB	1 mg	Log in	Get Quote
Goat anti Rabbit IgG (H/L):HRP	STAR124P	C E WB	1 mg	Log in	Get Quote
Sheep anti Rabbit IgG:FITC	STAR34B	C F	1 mg	Log in	Get Quote
Sheep anti Rabbit IgG:RPE	STAR35A	F	1 ml	Log in	Get Quote
Sheep anti Rabbit IgG:DyLight®488	STAR36D488GA	F IF WB	0.1 mg	Log in	Get Quote
Sheep anti Rabbit IgG:DyLight®680	STAR36D680GA	F IF WB	0.1 mg	Log in	Get Quote
Sheep anti Rabbit IgG:Dylight®800	STAR36D800GA	F IF WB	0.1 mg	Log in	Get Quote

Product Specific References

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