CXCL16 antibody

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Goat anti Mouse CXCL16:Preservative Free

Product Type: Polyclonal Antibody
Isotype: Polyclonal IgG
Specificity: CXCL16

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AHP2804Z Datasheet Datasheet SDS SDS	E WB	0.1 mg		Log in	Get Quote
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Goat anti Mouse CXCL16 antibody, recognizes C-X-C motif Chemokine 16 (CXCL16). Unlike most chemokines, CXCL16 is a membrane bound ligand anchored through transmembrane domains. Although a soluble form of CXCL16 is generated through proteolytic cleavage. Transmembrane CXCL16 is mainly expressed on macrophages, dendritic cells, B cells and various tumor cells. In this form, it acts as an adhesion molecule though the binding of its receptor CXCR6 expressed on other cells including T cells. Transmembrane CXCL16 also binds gram positive and gram negative bacteria, playing a role in innate and adaptive immune responses (Shimaoka et al. 2003).

Soluble CXCL16 has chemoattractant activity, and elicits this response through the receptor CXCR6 and plays al role in tumor progression. CXCL16 may be used as a biomarker for the evaluation of some tumor type prognoses (Richardsen et al. 2015, Shibata et al. 2020, Gooden et al. 2014).

Target Species: Mouse
Product Form: Purified IgG - lyophilized
Reconstitution: Reconstitute with 0.1 ml distilled water
Antiserum Preparation: Produced from sera of goats immunized with recombinant mouse CXCL16 and purified by affinity chromatography
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: None present
Carrier Free: Yes
Immunogen: E. coli derived recombinant mouse CXCL16
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml after reconstitution
Endotoxin Level: < 0.1 ng/μg of protein (< 1 EU/μg)
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch

Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.

This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA		0.5 ug/ml	2.0 ug/ml
Western Blotting		0.1 ug/ml	0.2 ug/ml

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt: Q8BSU2
Entrez Gene: Cxcl16
GO Terms: GO:0016021 integral to membrane; GO:0005041 low-density lipoprotein receptor activity; GO:0005044 scavenger receptor activity; GO:0005615 extracellular space; GO:0006935 chemotaxis; GO:0008009 chemokine activity