CD184 / CXCR4 antibody
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Goat anti Mouse CD184 / CXCR4
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- CD184 / CXCR4
- Region
- (N-TERMINAL)
Antibody Quality and 
Unrivaled 
| Goat anti Mouse CD184 / CXCR4 recognises an epitope within the N-terminal (NT) region of mouse CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1). Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B-lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates. This antibody is reported as being suitable for use in immunocytochemistry on mouse spleen leucocytes. |
- Target Species
- Mouse
- Species Cross-Reactivity
-
Target Species Cross Reactivity Xenopus - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to mouse CD184 / CXCR4 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin - Immunogen
- Synthetic peptide YSEEVGSGDYDSNKEPCFRDENVHFNR corresponding to amino acids 14-40 within the N-terminal region of mouse CD184 / CXCR4.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1/50000 | |
| Immunohistology - Paraffin | |
1/300 | |
| Western Blotting | |
1/1000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- ELISA
- This product is suitable for use in indirect ELISA applications.
- Histology Positive Control Tissue
- Spleen
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- RRID
- AB_2089371
- UniProt
- P70658
- Entrez Gene
- Cxcr4
- GO Terms
- GO:0001569 patterning of blood vessels
- GO:0001667 ameboidal cell migration
- GO:0001764 neuron migration
- GO:0016021 integral to membrane
- GO:0007281 germ cell development
- GO:0009887 organ morphogenesis
- GO:0007420 brain development
- GO:0008045 motor axon guidance
- GO:0008354 germ cell migration
- View More GO Terms
- GO:0009897 external side of plasma membrane
- GO:0016493 C-C chemokine receptor activity
- GO:0016494 C-X-C chemokine receptor activity
- GO:0030334 regulation of cell migration
- GO:0030426 growth cone
- GO:0042098 T cell proliferation
View more products with CD184 specificity
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