XEDAR antibody

Rabbit anti Human XEDAR

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
XEDAR

Product Code Applications Pack Size List Price Your Price Qty
AHP1182
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SDS Safety Datasheet SDS
WB 0.1 mg loader
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Rabbit anti Human XEDAR antibody detects human X-linked ectodermal dysplasia receptor (XEDAR), a ~33 kDa type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily. XEDAR is a homologue of the ectodermal dysplasia receptor (EDAR), and binds to an isoform of ectodysplasin termed EDA-A2. Binding of ectodysplasin to XEDAR results in the induction of apoptosis, and is thought to be involved ectodermal organ development. XEDAR may also be involved in skeletal muscle development.

Two predominant isoforms of XEDAR exist; XEDAR-s and XEDAR-L, produced by alternative splicing.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to XEDAR were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide
Immunogen
Recombinant human XEDAR.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 0.5 2.0ug/ml
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP1182 detects a band of approximately 33kDa in 293 cell lysates.

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Further Reading

  1. Sinha, S.K. et al. (2002) Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor.
    J Biol Chem. 277 (47): 44953-61.
  2. Sinha, S.K. & Chaudhary, P.M. (2004) Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism.
    J Biol Chem. 279 (40): 41873-81.
  3. Newton, K. et al. (2004) Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency.
    Mol Cell Biol. 24 (4): 1608-13.

Synonyms
EDA2R
TNFRSF27
RRID
AB_844693
UniProt
Q9HAV5
Entrez Gene
EDA2R
GO Terms
GO:0005031 tumor necrosis factor receptor activity
GO:0005887 integral to plasma membrane
GO:0009790 embryo development
GO:0008544 epidermis development
GO:0030154 cell differentiation
GO:0046330 positive regulation of JNK cascade
GO:0051092 positive regulation of NF-kappaB transcription factor activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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