Tissue Transglutaminase antibody

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Anti Tissue Transglutaminase Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with tissue transglutaminase antibody followed by detection with Goat anti Rabbit HRP conjugated(1/10,000,STAR208P) and visualized on the ChemiDoc MP with 55 second exposure. Arrow points to tissue transglutaminase (molecular weight 78 kDa)

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Rabbit anti Tissue Transglutaminase

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: Tissue Transglutaminase

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Rabbit anti Human tissue transglutaminase antibody recognizes tissue transglutaminase, also known as protein-glutamine gamma-glutamyltransferase 2, C polypeptide, TG(C), TGase C, TGase H, TGase-2, TGase-H, epididymis secretory protein Li 45, transglutaminase C, transglutaminase H and transglutaminase-2.

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. Encoded by the TGM2 gene, tissue transglutaminase acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. It is also the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for TGM2 (provided by RefSeq, Jul 2008).

Rabbit anti Human tissue transglutaminase antibody detects a band of 78 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti TGM2 detects a band of approximately 78 kDa in K562 cell lysates.
Product Form: Purified IgG - liquid
Preparation: Rabbit Ig fraction prepared by ammonium sulphate precipitation.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: KLH conjugated synthetic peptide between 429-458 amino acids from the Central region of human tissue transglutaminase
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: P21980
Entrez Gene: TGM2
GO Terms: GO:0003810 protein-glutamine gamma-glutamyltransferase activity; GO:0046872 metal ion binding; GO:0008415 acyltransferase activity; GO:0043277 apoptotic cell clearance; GO:0045785 positive regulation of cell adhesion