TIM-4 antibody

Rabbit anti TIM-4 (C-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
TIM-4
Region
(C-TERMINAL)

Product Code Applications Pack Size List Price Your Price Qty
AHP1188
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 mg loader
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loader
Search for Batch Specific Datasheets

Rabbit anti Human TIM-4 antibody recognizes the C-terminal (CT) region of T-cell immunoglobulin mucin-4 (TIM-4), also known as SMUCKLER. TIM-4 is a ~ 42 kDa type I membrane protein which is preferentially expressed on macrophages and dendritic cells. TIM-4 is the ligand of TIM-1, and binding leads to T-cell proliferation and cytokine production. Polymorphisms in the TIM-4 gene may be associated with a predisposition to asthma.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human TIM-4 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide
Immunogen
15 amino acid peptide sequence near the carboxy terminus of human TIM-4.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1.0 2.0ug/ml
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP1188 detects a band of approximately 54kDa in Jurkat cell lysate.

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Further Reading

  1. Meyers, J.H. et al. (2005) TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation.
    Nat Immunol. 6 (5): 455-64.
  2. Meyers, J.H. et al. (2005) The TIM gene family regulates autoimmune and allergic diseases.
    Trends Mol Med. 11 (8): 362-9.

Synonyms
T-CELL Immunoglobulin MUCIN-4
RRID
AB_2201850
UniProt
Q96H15
Entrez Gene
TIMD4
GO Terms
GO:0016021 integral to membrane
View more products with TIM-4 specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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