TIM-1 antibody

Rabbit anti TIM-1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
TIM-1

Product Code Applications Pack Size List Price Your Price Qty
AHP1187
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Rabbit anti TIM-1 antibody detects T cell immunoglobulin mucin-1 (TIM-1), which was first identified as the receptor used by hepatitis A for viral entry, it is also known as the hepatitis A virus cellular receptor- HAVCR (Curtiss and Colgan 2007), TIM -1 also acts as a receptor for other viruses, including Dengue, Ebola and Marburg (Kondratowicz et al. 2011). TIM-1 is a key cell surface protein that binds TIM-4, leading to T cell proliferation and T helper type 2 (Th2) cytokine production.

Two splice variants for human TIM-1 exist; TIM-1a is predominantly expressed in the liver, whilst TIM-1b is expressed in the kidney. Expression of TIM-1 in the kidney is thought to be upregulated in damaged tissue, and is thought to assist healing.

TIM-1 polymorphisms are associated with susceptibility to allergy and asthma (Mcintire et al. 2004).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human TIM-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide
Immunogen
16 amino acid peptide sequence near the centre of human TIM-1.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1.0 2.0ug/ml
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP1187 detects a band of approximately 49kDa in human uterus tissue lysate.

Description Product Code Applications Pack Size List Price Your Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
List Price Your Price
loader
Description Goat anti Rabbit IgG (Fc):Biotin
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
List Price Your Price
loader
Description Goat anti Rabbit IgG (Fc):FITC
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
List Price Your Price
loader
Description Goat anti Rabbit IgG (Fc):HRP
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
List Price Your Price
loader
Description Goat anti Rabbit IgG (H/L):HRP
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
List Price Your Price
loader
Description Sheep anti Rabbit IgG:FITC
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
List Price Your Price
loader
Description Sheep anti Rabbit IgG:RPE

Description Product Code Applications Pack Size List Price Your Price Quantity
TidyBlot Western Blot Detection Reagent:HRP STAR209P WB* 0.5 ml
List Price Your Price
Description TidyBlot Western Blot Detection Reagent:HRP

Further Reading

  1. Meyers, J.H. et al. (2005) The TIM gene family regulates autoimmune and allergic diseases.
    Trends Mol Med. 11 (8): 362-9.
  2. Hein, R.M. & Woods, M.L. (2007) TIM-1 regulates macrophage cytokine production and B7 family member expression.
    Immunol Lett. 108 (1): 103-8.

Synonyms
T Cell Immunoglobulin Mucin 1
RRID
AB_2116565
UniProt
Q96D42
Entrez Gene
HAVCR1
GO Terms
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0044419 interspecies interaction between organisms
View more products with TIM-1 specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Human Products