TAK1 antibody

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Anti TAK1 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with TAK1 antibody followed by detection with Goat anti Rabbit HRP conjugated(1/10,000,STAR208P) and visualized on the ChemiDoc MP with 11 second exposure. Arrow points to TAK1 (molecular weight 82 kDa)

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Rabbit anti TAK1

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: TAK1

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VPA00224 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human TAK1 antibody recognizes TGF-beta activated kinase 1 (TAK1), also known as mitogen-activated protein kinase kinase kinase 7 and transforming growth factor-beta-activated kinase 1.

Encoded by MAP3K7 gene, TAK1 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported (provided by RefSeq, Jul 2008).

Rabbit anti Human TAK1 antibody detects a band of 82 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti TAK1 detects a band of approximately 82 kDa in HeLa cell lysates.
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Preparation: Rabbit polyclonal antibody purified by affinity chromatography on Protein G.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: KLH conjugated synthetic peptide between 574-606 amino acids from the C-terminal region of human TAK1
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Target Species	Cross Reactivity
Mouse

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: O43318
Entrez Gene: MAP3K7
GO Terms: GO:0000187 activation of MAPK activity; GO:0005515 protein binding; GO:0000287 magnesium ion binding; GO:0002726 positive regulation of T cell cytokine production; GO:0002755 MyD88-dependent toll-like receptor signaling pathway; GO:0002756 MyD88-independent toll-like receptor signaling pathway; GO:0005829 cytosol; GO:0004709 MAP kinase kinase kinase activity; GO:0005524 ATP binding; View More GO Terms; GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex; GO:0007179 transforming growth factor beta receptor signaling pathway; GO:0007250 activation of NF-kappaB-inducing kinase activity; GO:0007252 I-kappaB phosphorylation; GO:0007254 JNK cascade; GO:0008063 Toll signaling pathway; GO:0010008 endosome membrane; GO:0032743 positive regulation of interleukin-2 production; GO:0034130 toll-like receptor 1 signaling pathway; GO:0034134 toll-like receptor 2 signaling pathway; GO:0034138 toll-like receptor 3 signaling pathway; GO:0034142 toll-like receptor 4 signaling pathway; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade; GO:0043507 positive regulation of JUN kinase activity; GO:0043966 histone H3 acetylation; GO:0045087 innate immune response; GO:0050852 T cell receptor signaling pathway; GO:0050870 positive regulation of T cell activation; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051403 stress-activated MAPK cascade