RBBP7 antibody

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Rabbit anti RBBP7

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00360
Datasheet
WB
MSDS
100 µl loader

Rabbit anti Human RBBP7 antibody recognizes RBBP7, also known as G1/S transition control protein-binding protein RbAp46, histone acetyltransferase type B subunit 2, histone-binding protein RBBP7, nucleosome-remodeling factor subunit RBAP46, retinoblastoma-binding protein 7, retinoblastoma-binding protein RbAp46 and retinoblastoma-binding protein p46.

RBBP7 is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. RBBP7 is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for RBBP7 (provided by RefSeq, Nov 2010).

Rabbit anti Human RBBP7 antibody detects a band of 52 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti RBBP7 detects a band of approximately 52 kDa in MOLT-4 cell lysate
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 1-30 of human RBBP7

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
Q16576
Entrez Gene
RBBP7
GO Terms
GO:0006260 DNA replication
GO:0005515 protein binding
GO:0006350 transcription
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0016581 NuRD complex
GO:0030308 negative regulation of cell growth
GO:0034080 CenH3-containing nucleosome assembly at centromere
GO:0035098 ESC/E(Z) complex
GO:0045449 regulation of transcription
GO:0070370 cellular heat acclimation
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory
For research purposes only

Applications of RBBP7 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml