PDHA1 antibody
Rabbit anti PDHA1
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- PDHA1
Antibody Quality and Performance Guarantee
| Rabbit anti PDHA1 antibody recognizes pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, also known as PDHE1-A type 1 and PHE1A. The PDHA1 gene encodes part of the mitochondrial pyruvate dehydrogenase (PDH) complex, which converts pyruvate to acetyl-CoA and CO2. PDHA1 deficiency leads to mitochondrial dysfunction, and is associated with poor outcome in multiple cancer types (Song et al. 2018). The gene encoding PDHA1 is located on the X-chromosome, and mutations result in metabolic disorders, intellectual disability and early death (Yoshida et al. 2017). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to PDHA1 was raised by repeated immunization of rabbits with highly purified antigen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.05% ProClin 300
50% Glycerol - Immunogen
- Recombinant protein of human PDHA1
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- ProClin is a trademark of The Dow Chemical Company (“Dow”) or an affiliated company of Dow.
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/50 | 1/200 |
| Western Blotting | |
1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P08559
- Entrez Gene
- PDHA1
- GO Terms
- GO:0005515 protein binding
- GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
- GO:0005759 mitochondrial matrix
- GO:0006090 pyruvate metabolic process
- GO:0006096 glycolysis
- GO:0055114 oxidation-reduction process
- GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
AHP3006
153400
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Request a different product with this specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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