PDHA1 antibody

Rabbit anti PDHA1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
PDHA1

Product Code Applications Pack Size List Price Your Price Qty
AHP3006
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P WB 50 µl loader
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Rabbit anti PDHA1 antibody recognizes pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, also known as PDHE1-A type 1 and PHE1A.

The PDHA1 gene encodes part of the mitochondrial pyruvate dehydrogenase (PDH) complex, which converts pyruvate to acetyl-CoA and CO2. PDHA1 deficiency leads to mitochondrial dysfunction, and is associated with poor outcome in multiple cancer types (Song et al. 2018). The gene encoding PDHA1 is located on the X-chromosome, and mutations result in metabolic disorders, intellectual disability and early death (Yoshida et al. 2017).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to PDHA1 was raised by repeated immunization of rabbits with highly purified antigen
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Recombinant protein of human PDHA1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/50 1/200
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P08559
Entrez Gene
PDHA1
GO Terms
GO:0005515 protein binding
GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
GO:0005759 mitochondrial matrix
GO:0006090 pyruvate metabolic process
GO:0006096 glycolysis
GO:0055114 oxidation-reduction process
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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