PDHA1 antibody



The PDHA1 gene encodes part of the mitochondrial pyruvate dehydrogenase (PDH) complex, which converts pyruvate to acetyl-CoA and CO2. PDHA1 deficiency leads to mitochondrial dysfunction, and is associated with poor outcome in multiple cancer types (Song et al. 2018). The gene encoding PDHA1 is located on the X-chromosome, and mutations result in metabolic disorders, intellectual disability and early death (Yoshida et al. 2017).
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to PDHA1 was raised by repeated immunization of rabbits with highly purified antigen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Recombinant protein of human PDHA1
Storage Information
- Storage
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P08559
- Entrez Gene
- PDHA1
- GO Terms
- GO:0005515 protein binding
- GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
- GO:0005759 mitochondrial matrix
- GO:0006090 pyruvate metabolic process
- GO:0006096 glycolysis
- GO:0055114 oxidation-reduction process
- GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
- Regulatory
- For research purposes only
Applications of PDHA1 antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Paraffin | 1/50 | 1/200 | |
Western Blotting | 1/500 | 1/2000 |
Secondary Antibodies Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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Sheep anti Rabbit IgG:DyLight®488 | STAR36D488GA | F IF WB | 0.1 mg | ||
Sheep anti Rabbit IgG:DyLight®680 | STAR36D680GA | F IF WB | 0.1 mg | ||
Sheep anti Rabbit IgG:Dylight®800 | STAR36D800GA | F IF WB | 0.1 mg |
Fluorescent Spectraviewer
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