NFkB p105 (pSer907) antibody

Rabbit anti NFkB p105 (pSer907)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
NFkB p105 (pSer907)

Product Code Applications Pack Size List Price Your Price Qty
AHP2658
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SDS Safety Datasheet SDS
WB 50 µl loader
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Rabbit anti NFkB p105 (pSer907) antibody recognizes human nuclear factor NF-kappa-B (NFkB) p105 subunit, also known as DNA-binding factor KBF1, EBP-1 or nuclear factor of kappa light polypeptide gene enhancer in B-cells, when phosphorylated at serine 907.

NFkB p105 is a large precursor protein that is cleaved at its C-terminus (which mainly contains ankyrin repeats) by the ubiquitin/proteasome pathway into the NFkB p50 subunit. The p50 subunit interacts with members of the Rel protein family to form transcription factors. The NFkB pathway plays a critical role in mediating immune responses after infection and has been implicated in a variety of diseases ranging from autoimmune disorders to cancer.

NFkB is phosphorylated at serine 907 by GSK3-beta (Demarchi et al. 2003).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to NFkB p105 (pSer907) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Phospho specific-peptide corresponding to residues surrounding serine 907 of human NFkB p105
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Further Reading

  1. Demarchi, F. et al. (2003) Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability.
    J Biol Chem. 278 (41): 39583-90.

UniProt
P19838
Entrez Gene
NFKB1
GO Terms
GO:0005515 protein binding
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0006915 apoptosis
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005654 nucleoplasm
GO:0006366 transcription from RNA polymerase II promoter
GO:0006916 anti-apoptosis
GO:0006954 inflammatory response
GO:0008063 Toll signaling pathway
GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010843 promoter binding
GO:0010884 positive regulation of lipid storage
GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
GO:0010957 negative regulation of vitamin D biosynthetic process
GO:0016563 transcription activator activity
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032269 negative regulation of cellular protein metabolic process
GO:0032375 negative regulation of cholesterol transport
GO:0033256 I-kappaB/NF-kappaB complex
GO:0034130 toll-like receptor 1 signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0045087 innate immune response
GO:0048011 nerve growth factor receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0090263 positive regulation of canonical Wnt receptor signaling pathway
View more products with NFKB specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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