MyD88 antibody
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WB ResetRabbit anti MyD88 (C-Terminal)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- MyD88
- Region
- (C-TERMINAL)
Antibody Quality and Performance Guarantee
| Rabbit anti Human MyD88 antibody recognizes human MyD88, an adaptor molecule involved in the interleukin-1 (IL-1) signaling pathway. MyD88 is also considered to be a general adaptor/regulator protein of the Toll/IL-R1 receptor family. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human MyD88 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.02% Sodium Azide - Immunogen
- Synthetic peptide corresponding to amino acids 279-296 of MyD88.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/500 |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Further Reading
-
Medzhitov, R. et al. (1998) MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
Mol. Cell. 2: 253-8.
- RRID
- AB_2282235
- UniProt
- Q99836
- Entrez Gene
- MYD88
- GO Terms
- GO:0005886 plasma membrane
- GO:0002755 MyD88-dependent toll-like receptor signaling pathway
- GO:0005829 cytosol
- GO:0004888 transmembrane receptor activity
- GO:0005123 death receptor binding
- GO:0006916 anti-apoptosis
- GO:0006954 inflammatory response
- GO:0008063 Toll signaling pathway
- GO:0010008 endosome membrane
- View More GO Terms
- GO:0031224 intrinsic to membrane
- GO:0032740 positive regulation of interleukin-17 production
- GO:0032747 positive regulation of interleukin-23 production
- GO:0032755 positive regulation of interleukin-6 production
- GO:0034130 toll-like receptor 1 signaling pathway
- GO:0034134 toll-like receptor 2 signaling pathway
- GO:0034142 toll-like receptor 4 signaling pathway
- GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0045087 innate immune response
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0050727 regulation of inflammatory response
- GO:0070555 response to interleukin-1
AHP552
152836
160802
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