MIP-1 Beta antibody
Rabbit anti Human MIP-1 Beta
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- MIP-1 Beta
Rabbit anti Human MIP-1 beta antibody recognizes human MIP-1 beta, otherwise known as CCL4, a 69 amino acid member of the CC chemokine family, shown to signal through the chemokine receptors CCR1, CCR2 and CCR5. MIP-1 beta is involved in host defence against invading pathogens, acting as a regulator of activation and trafficking of inflammatory cells, such as monocytes, B cells, NK cells, neutrophils, dendritic cells and CD4+ lymphocytes. The secretion of MIP-1 beta by CD8+ lymphocytes has been shown to act as a major HIV-suppressive factor (HIV-SF) through binding to CCR5, identified as a coreceptor for HIV-1 target cell entry. |
- Target Species
- Human
- Product Form
- Purified IgG - lyophilized
- Reconstitution
- Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended. NB: For functional studies do not add azide.
- Antiserum Preparation
- Antisera to human MIP-1 beta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Carrier Free
- Yes
- Immunogen
- Recombinant human MIP-1 beta.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | 0.5ug/ml | ||
Functional Assays | 1.75 | 3.0ug/ml | |
Immunohistology - Paraffin 1 | |||
Western Blotting | 0.1 | 0.2ug/ml |
- 1 This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
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References for MIP-1 Beta antibody
-
Cocchi, F. et al. (1995) Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.
Science. 270 (5243): 1811-5.
Further Reading
-
Menten, P. et al. (2002) Macrophage inflammatory protein-1.
Cytokine Growth Factor Rev. 13 (6): 455-81.
- Synonyms
- CCL4
- RRID
- AB_808652
- UniProt
- P13236
- Entrez Gene
- CCL4
- GO Terms
- GO:0009615 response to virus
- GO:0007155 cell adhesion
- GO:0004716 receptor signaling protein tyrosine kinase activity
- GO:0005615 extracellular space
- GO:0006928 cellular component movement
- GO:0006935 chemotaxis
- GO:0006954 inflammatory response
- GO:0006955 immune response
- GO:0007163 establishment or maintenance of cell polarity
- View More GO Terms
- GO:0007267 cell-cell signaling
- GO:0008009 chemokine activity
- GO:0019079 viral genome replication
AHP1043
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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