Rabbit anti Human MDC antibody
recognizes human MDC, also known as macrophage-derived cytokine, CCL22, CC chemokine STCP-1, Small-inducible cytokine A22 or Stimulated T-cell chemotactic protein 1. MDC is a 93 amino acid, ~10.6 kDa member of the CC chemokine family expressed by macrophages, monocyte-derived dendritic cells, epithelial cells, fibroblasts and highly expressed in the thymus.
MDC acts as a chemoattractant for monocytes, dendritic cells, activated T lymphocytes and NK cells, through binding to chemokine (C-C motif) receptor 4 (CCR4). CCR4 is selectively expressed by Th2 cells and several studies have revealed a link between MDC and another ligand of CCR4, known as activation-regulated chemokine (TARC/CCL17), with Th2-mediated inflammatory disorders such as atopic dermatitis and ulcerative colitis (Judge et al. 2001
- Target Species
- Product Form
- Purified IgG - lyophilised
- Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended. NB: For functional studies do not add azide.
- Antiserum Preparation
- Antisera to human MDC were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Recombinant human MDC.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Prior to reconstitution store at +4oC.
After reconstitution store at -20oC.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of reconstitution.
- Entrez Gene
- GO Terms
response to virus
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of MDC antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2020 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Imai, T. et al. (1998) Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.
J Biol Chem. 273 (3): 1764-8.