Inhibin Beta B antibody
Rabbit anti Human inhibin beta B antibody recognizes inhibin beta B, also known as INHBB, activin AB beta polypeptide and activin beta-B chain.
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extra-gonadal tissues may vary several fold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion (provided by RefSeq, Jul 2008).
Rabbit anti Human inhibin beta B antibody detects a band of 52 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extra-gonadal tissues may vary several fold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion (provided by RefSeq, Jul 2008).
Rabbit anti Human inhibin beta B antibody detects a band of 52 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti inhibin beta B detects a band of approximately 52 kDa in human adipose tissue
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- KLH-conjugated synthetic peptide corresponding to aa 369-397 of human inhibin beta B
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles
- Guarantee
- As supplied, 12 months from date of despatch
More Information
- UniProt
- P09529
- Entrez Gene
- INHBB
- GO Terms
- GO:0001541 ovarian follicle development
- GO:0006952 defense response
- GO:0005576 extracellular region
- GO:0005125 cytokine activity
- GO:0005179 hormone activity
- GO:0040007 growth
- GO:0008083 growth factor activity
- GO:0009267 cellular response to starvation
- GO:0046881 positive regulation of follicle-stimulating hormone secretion
- GO:0046882 negative regulation of follicle-stimulating hormone secretion
- GO:0032869 cellular response to insulin stimulus
- GO:0032924 activin receptor signaling pathway
- GO:0046789 host cell surface receptor binding
- GO:0042803 protein homodimerization activity
- GO:0045444 fat cell differentiation
- GO:0046676 negative regulation of insulin secretion
- GO:0048178 negative regulation of hepatocyte growth factor biosynthetic process
- GO:0048471 perinuclear region of cytoplasm
- GO:0060279 positive regulation of ovulation
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of Inhibin Beta B antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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