Inhibin Beta B antibody

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Rabbit anti Inhibin Beta B

Rabbit anti human inhibin beta B antibody recognizes the protein inhibin beta B, also known as activin beta B chain or acitivin AB beta polypeptide. This antibody has been extensively validated for western blotting using whole cell lysates.

Product Type
PrecisionAb™ Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
VPA00277 WB 100 µl
Rabbit anti Human inhibin beta B antibody recognizes inhibin beta B, also known as INHBB, activin AB beta polypeptide and activin beta-B chain.

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extra-gonadal tissues may vary several fold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion (provided by RefSeq, Jul 2008).

Rabbit anti Human inhibin beta B antibody detects a band of 52 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti inhibin beta B detects a band of approximately 52 kDa in human adipose tissue
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 369-397 of human inhibin beta B
Instructions For Use
Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles
Shelf Life
As supplied, 12 months from date of despatch

More Information

UniProt
P09529 Related reagents
Entrez Gene
INHBB Related reagents
GO Terms
GO:0001541 ovarian follicle development
GO:0006952 defense response
GO:0005576 extracellular region
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0040007 growth
GO:0008083 growth factor activity
GO:0009267 cellular response to starvation
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0046882 negative regulation of follicle-stimulating hormone secretion
GO:0032869 cellular response to insulin stimulus
GO:0032924 activin receptor signaling pathway
GO:0046789 host cell surface receptor binding
GO:0042803 protein homodimerization activity
GO:0045444 fat cell differentiation
GO:0046676 negative regulation of insulin secretion
GO:0048178 negative regulation of hepatocyte growth factor biosynthetic process
GO:0048471 perinuclear region of cytoplasm
GO:0060279 positive regulation of ovulation
Acknowledgements
PrecisionAbâ„¢ is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of Inhibin Beta B antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P 2 ml WB

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