IL-23 antibody
Rabbit anti Human Interleukin-23 (C-Terminal)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- IL-23
- Region
- (C-TERMINAL)
Antibody Quality and Performance Guarantee
| Rabbit anti Human IL-23 antibody recognizes the C-terminal (CT) domain of human interleukin-23 (IL-23), a ~21 kDa heterodimeric cytokine structurally related to IL-12. IL-23 is composed of a p19 subunit encoded by the IL23A gene, and a p40 subunit of interleukin-12 (IL12B). IL-23 is expressed mainly by activated macrophages and dendritic cells, and plays an important role in bridging innate and adaptive responses. IL-23 activates a subset of T cells called Th17 cells, which are characterised by the production of interleukin-17. The IL-23/IL-17 pathway is essential for the induction and maintenance of brain and joint inflammatory autoimmune diseases, including Guillain Barre Syndrome, Multiple sclerosis and rheumatoid arthritis. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human IL-23 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.02% Sodium Azide (NaN3) - Immunogen
- A 14 amino acid peptide from near the carboxy-terminus of human IL-23.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Frozen |  |
10ug/ml | |
| Western Blotting | |
1 | 2ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Raji cells.
- Western Blotting
- AHP1173 detects a band of approximately 24kDa in Raji cell lysates
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Sheep anti Rabbit IgG:RPE | ||||||
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB * | 0.5 ml | Log in | |||
| List Price | Your Price | ||||||
| Log in | |||||||
| Description | TidyBlot Western Blot Detection Reagent:HRP | ||||||
Further Reading
-
Kikly, K. et al. (2006) The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation.
Curr Opin Immunol. 18 (6): 670-5. -
Hu, W. et al. (2006) Interleukin 23 in acute inflammatory demyelination of the peripheral nerve.
Arch Neurol. 63 (6): 858-64. -
Langrish, C.L. et al. (2004) IL-12 and IL-23: master regulators of innate and adaptive immunity.
Immunol Rev. 202: 96-105. -
Hunter, C.A. (2005) New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions.
Nat Rev Immunol. 5 (7): 521-31.
- RRID
- AB_844622
- UniProt
- Q9NPF7
- Entrez Gene
- IL23A
- GO Terms
- GO:0001916 positive regulation of T cell mediated cytotoxicity
- GO:0002230 positive regulation of defense response to virus by host
- GO:0002827 positive regulation of T-helper 1 type immune response
- GO:0009615 response to virus
- GO:0005125 cytokine activity
- GO:0006954 inflammatory response
- GO:0050829 defense response to Gram-negative bacterium
- GO:0010535 positive regulation of activation of JAK2 kinase activity
- GO:0032693 negative regulation of interleukin-10 production
- View More GO Terms
- GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
- GO:0032729 positive regulation of interferon-gamma production
- GO:0032733 positive regulation of interleukin-10 production
- GO:0032735 positive regulation of interleukin-12 production
- GO:0032740 positive regulation of interleukin-17 production
- GO:0032760 positive regulation of tumor necrosis factor production
- GO:0032819 positive regulation of natural killer cell proliferation
- GO:0034105 positive regulation of tissue remodeling
- GO:0042104 positive regulation of activated T cell proliferation
- GO:0042346 positive regulation of NF-kappaB import into nucleus
- GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein
- GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
- GO:0042520 positive regulation of tyrosine phosphorylation of Stat4 protein
- GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
- GO:0043382 positive regulation of memory T cell differentiation
- GO:0045087 innate immune response
- GO:0045672 positive regulation of osteoclast differentiation
- GO:0048771 tissue remodeling
- GO:0050729 positive regulation of inflammatory response
- GO:0051135 positive regulation of NK T cell activation
- GO:0051142 positive regulation of NK T cell proliferation
- GO:0070743 interleukin-23 complex
AHP1173
144587
145509
164761
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
View more products with IL-23 specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
View all Anti-Human ProductsAlways be the first to know.
When we launch new products and resources to help you achieve more in the lab.
Yes, sign me up