Rabbit anti GSK3 Alpha (pSer21) antibody recognizes GSK3 alpha when phosphorylated at serine 21. GSK3 is a member of the CMGC family of kinases. GSK3 comprises two isoforms, alpha and beta, with 85% total homology and 98% homology between kinase domains. GSK3 alpha is phosphorylated at serine 21 by protein kinase A, AKT and ribosomal S6 kinases p90RSK and p70S6K. Phosphorylation of GSK3 alpha at serine 21 leads to inactivation of GSK3 alpha.
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to GSK3 ALPHA (pSer21) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Phospho specific-peptide corresponding to residues surrounding serine 21 of human GSK3 ALPHA
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
protein serine/threonine kinase activity
insulin receptor signaling pathway
negative regulation of UDP-glucose catabolic process
beta-catenin destruction complex
protein kinase A catalytic subunit binding
positive regulation of protein catabolic process
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
nerve growth factor receptor signaling pathway
tau-protein kinase activity
negative regulation of transferase activity
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of GSK3 Alpha (pSer21) antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available