GSK3 Alpha (pSer21) antibody

Rabbit anti GSK3 Alpha (pSer21)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
GSK3 Alpha (pSer21)

Product Code Applications Pack Size List Price Your Price Qty
AHP2625
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 50 µl loader
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loader
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Rabbit anti GSK3 Alpha (pSer21) antibody recognizes GSK3 alpha when phosphorylated at serine 21. GSK3 is a member of the CMGC family of kinases. GSK3 comprises two isoforms, alpha and beta, with 85% total homology and 98% homology between kinase domains. GSK3 alpha is phosphorylated at serine 21 by protein kinase A, AKT and ribosomal S6 kinases p90RSK and p70S6K. Phosphorylation of GSK3 alpha at serine 21 leads to inactivation of GSK3 alpha.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to GSK3 ALPHA (pSer21) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Phospho specific-peptide corresponding to residues surrounding serine 21 of human GSK3 ALPHA
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P49840
Entrez Gene
GSK3A
GO Terms
GO:0005829 cytosol
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0006468 protein phosphorylation
GO:0008286 insulin receptor signaling pathway
GO:0010905 negative regulation of UDP-glucose catabolic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0030877 beta-catenin destruction complex
GO:0034236 protein kinase A catalytic subunit binding
GO:0045732 positive regulation of protein catabolic process
GO:0046325 negative regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048011 nerve growth factor receptor signaling pathway
GO:0050321 tau-protein kinase activity
GO:0051348 negative regulation of transferase activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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