GITRL antibody
Rabbit anti Human GITRL antibody recognizes Glucocorticoid-Induced TNF-Related Ligand (GITRL) also known as activation-inducible TNR-related ligand and TNFSF18.
GITRL is expressed in many components of the innate and adaptive immune system, but is mainly expressed on antigen presenting cells (Nocentini et al. 2007).
GITRL is a ligand of the receptor GITR, upon binding of its ligand, GITR is activated and plays a role in autoimmune/inflammatory processes and regulates leukocyte extravasation (Krausz et al. 2007, Nocentini et al. 2007).
GITRL is expressed in many components of the innate and adaptive immune system, but is mainly expressed on antigen presenting cells (Nocentini et al. 2007).
GITRL is a ligand of the receptor GITR, upon binding of its ligand, GITR is activated and plays a role in autoimmune/inflammatory processes and regulates leukocyte extravasation (Krausz et al. 2007, Nocentini et al. 2007).
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - lyophilized
- Reconstitution
- Reconstitute with 0.1 ml distilled water
- Antiserum Preparation
- Produced from sera of rabbits immunized with recombinant human AITRL and purified by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Carrier Free
- Yes
- Immunogen
- E. coli derived recombinant human GITRL
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml after reconstitution
- Endotoxin Level
- < 0.1 ng/μg of protein (< 1 EU/μg)
Storage Information
- Storage
- Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q9UNG2
- Entrez Gene
- TNFSF18
- GO Terms
- GO:0016021 integral to membrane
- GO:0007165 signal transduction
- GO:0005125 cytokine activity
- GO:0005164 tumor necrosis factor receptor binding
- GO:0005615 extracellular space
- GO:0006916 anti-apoptosis
- GO:0006955 immune response
- GO:0007267 cell-cell signaling
- Regulatory
- For research purposes only
Applications of GITRL antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | 0.5 ug/ml | 2.0 ug/ml | |
| Western Blotting | 0.1 ug/ml | 0.2 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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