Erythropoietin Receptor antibody

Rabbit anti Erythropoietin Receptor

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
Erythropoietin Receptor

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VPA00265
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Rabbit anti Human erythropoietin receptor antibody recognizes the erythropoietin receptor also known as EPO-R and EPOR.

The erythropoietin receptor is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates JAK2 tyrosine kinase which activates different intracellular pathways including Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of the erythropoietin receptor may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants (provided by RefSeq, May 2010).

Rabbit anti Human erythropoietin receptor antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti erythropoietin receptor detects a band of approximately 55 kDa in K562 cell lysate.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 470-504 of human erythropoietin receptor
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P19235
Entrez Gene
EPOR
GO Terms
GO:0005576 extracellular region
GO:0004900 erythropoietin receptor activity
GO:0005887 integral to plasma membrane
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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