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DR6 antibody

Rabbit anti Human DR6 (aa42-56)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
DR6
Region
(aa42-56)

Product Code Applications Pack Size List Price Your Price Qty
AHP585
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 mg loader
List Price Your Price
loader

Rabbit anti Human DR6 antibody recognizes human Tumor necrosis factor receptor superfamily member 21, also known as death domain containing receptor DR6, Death receptor 6 or CD358. DR6 is a 655 amino acid ~72 kDa type 1 single pass transmembrane glycoprotein with four extracellular cysteine rich repeats and a single cytoplasmic death domain. DR6 is widely expressed in human tissues and cell lines. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK (Pan et al. 1998).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to DR6 (NT) were raised by repeated immunisation of rabbit with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide
Immunogen
Peptide corresponding to amino acids 42-56 of human DR6 precursor.
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at +4oC.

This product should be stored undiluted.

DO NOT FREEZE.
Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

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References for DR6 antibody

  1. Achiron, A. et al. (2009) Molecular profiling of glatiramer acetate early treatment effects in multiple sclerosis.
    Dis Markers. 27: 63-73.

RRID
AB_323405
UniProt
O75509
Entrez Gene
TNFRSF21
GO Terms
GO:0005515 protein binding
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0005737 cytoplasm
GO:0044255 cellular lipid metabolic process

AHP585

040613

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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