Rabbit anti Human DR6 antibody
recognizes human Tumor necrosis factor receptor superfamily member 21, also known as death domain containing receptor DR6, Death receptor 6 or CD358. DR6 is a 655 amino acid ~72 kDa type 1 single pass transmembrane glycoprotein with four extracellular cysteine rich repeats
and a single cytoplasmic death
domain. DR6 is widely expressed in human tissues and cell lines. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK (Pan et al. 1998
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to DR6 (NT) were raised by repeated immunisation of rabbit with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Peptide corresponding to amino acids 42-56 of human DR6 precursor.
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Store at +4oC.
This product should be stored undiluted.
DO NOT FREEZE.
Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to membrane
cellular lipid metabolic process
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of DR6 antibody
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
References for DR6 antibody
Achiron, A. et al. (2009) Molecular profiling of glatiramer acetate early treatment effects in multiple sclerosis.
Dis Markers. 27: 63-73.
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