Rabbit anti Human DR3 antibody recognises a ~59 kDa apoptosis related protein designated DR3 (death receptor-3).
DR3 is a cell surface receptor with a death domain, with functional similarities to TNFR1 and Fas (CD95).
The ligand for DR3 has very recently been identified and has been termed Apo-3L. DR3 itself has also been called Wsl-1, Apo-3, TRAMP and LARD, and functionally induces apoptosis and NF-κB activation.
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to DR3 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Peptide sequence QGGTRSPRCDCAGDFH from amino terminus of human DR3
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Store at +4oC for one month or at -20oC for longer.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of DR3 antibody
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Chinnaiyan, A.M. et al. (1996) Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.
Science. 274 (5289): 990-2.
Marsters, S.A. et al. (1998) Identification of a ligand for the death-domain-containing receptor Apo3.
Curr Biol. 8 (9): 525-8.
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