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DNA Methyltransferase 1 antibody

Rabbit anti DNA Methyltransferase 1

Product Type
PrecisionAb Polyclonal
Polyclonal IgG
DNA Methyltransferase 1

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Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 100 µl loader
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Rabbit anti Human DNA methyltransferase 1 antibody recognizes human DNA (cytosine-5) methyltransferase 1, also known as DNMT1, CXXC-type zinc finger protein 9, MCMT or DNA methyltransferase HsaI. DNA methyltransferase 1 is a 1616 amino acid member of the C5-methyltransferase family, bearing 2 BAH domains and single CXXC-type zinc finger, DMAP-interaction and SAM-dependent MTase C5-type domains. The epitope recognized by Rabbit anti Human DNA methyltransferase 1 antibody maps to a region between residues 700 and 750 of human DNMT1.

DNMT1 is a nuclear enzyme with a major role in the maintenance of DNA methylation patterns after replication (Song et al. 2012). DNA methylation is significant for epigenetic regulation of gene expression, X chromosome inactivation, genomic imprinting, and development (Lee et al. 2001). Overexpression of DNMT1 has been detected in several human cancers (Robertson et al. 1999).

Rabbit anti Human DNA methyltransferase 1 antibody recognizes human DNA methyltransferase 1 as a band of ~180 kDa in multiple human cell lysates by western blotting under reducing conditions.
PrecisionAb Antibodies

Target Species
Western Blotting
Anti DNA Methyltransferase 1 antibody detects a band of approximately 180 kDa in HEK293 cell lysates.
Product Form
Purified IgG - liquid
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
TRIS-citrate/Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Synthetic peptide corresponding to a region within human DNMT1 encoded within exon 25
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml.
For research purposes only.
12 months from date of despatch.
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Entrez Gene
GO Terms
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0003677 DNA binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0005634 nucleus
GO:0006350 transcription
GO:0008134 transcription factor binding
GO:0010216 maintenance of DNA methylation
GO:0010628 positive regulation of gene expression
GO:0016568 chromatin modification
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051573 negative regulation of histone H3-K9 methylation


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