DcR3 antibody

Rabbit anti Human DcR3 (N-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
DcR3
Region
(N-TERMINAL)

Product Code Applications Pack Size List Price Your Price Qty
AHP1603
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
P * WB 0.1 mg loader
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Search for Batch Specific Datasheets

Rabbit anti Human DcR3 (N-Terminal) antibody recognizes the amino Terminal of human DcR3, otherwise known as Decoy Receptor 3, a ~33 kDa member of the tumour necrosis factor receptor superfamily.

DcR3 acts as a receptor for FasL and LIGHT, preventing them from binding to their cell death receptors and thereby inhibiting apoptosis.

DcR3 is a soluble decoy receptor found in adult stomach, spinal cord, lymph node, trachea, spleen and lung. It may also be found in fetal lung, brain and liver and is highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human DcR3 (NT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
Immunogen
A peptide corresponding to amino acids near the amino-terminus of human DcR3 precursor.
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1 1ug/ml
Western Blotting 0.5 1.0ug/ml
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP1603 detects a band of approximately 33kDa in human heart lysate.

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Synonyms
TNFRSF6B
RRID
AB_2303707
UniProt
O95407
Entrez Gene
TNFRSF6B
GO Terms
GO:0005515 protein binding
GO:0006915 apoptosis
GO:0005576 extracellular region
GO:0004872 receptor activity
GO:0005625 soluble fraction
GO:0006916 anti-apoptosis
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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