Cytochrome P450 1B1 antibody

Rabbit anti Cytochrome P450 1B1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Cytochrome P450 1B1

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AHP2731
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SDS Safety Datasheet SDS
IF WB 50 µl loader
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Rabbit anti cytochrome P450 1B1 antibody recognizes cytochrome P450 1B1, also known as CYPIB1. It is a member of the cytochrome P450 superfamily of enzymes. It catalyses the hydroxylation of 17-β-oestradiol at the C4 position (Jefcoate et al. 2000, Potter et al. 2002). A number of Cytochrome P450 1B1 mutations are associated with primary congenital glaucoma (Rauf et al. 2016).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to cytochrome P450 1B1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human cytochrome P450 1B1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunofluorescence 1/50 1/200
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti cytochrome P450 1B1 antibody detects a band of approximately 62 kDa in various cell and tissue lysates under reducing conditions

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UniProt
Q16678
Entrez Gene
CYP1B1
GO Terms
GO:0009055 electron carrier activity
GO:0005515 protein binding
GO:0005789 endoplasmic reticulum membrane
GO:0005792 microsome
GO:0055114 oxidation-reduction process
GO:0006805 xenobiotic metabolic process
GO:0007601 visual perception
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0070330 aromatase activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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