CD261 antibody
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WB IC ResetRabbit anti Human CD261 (C-Terminal)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- CD261
- Region
- (C-TERMINAL)
Antibody Quality and 
Unrivaled 
| Rabbit anti Human CD261 antibody recognizes the ~57 kDa apoptosis related protein designated Death receptor 4, also known as CD261 or DR4. CD261 is a cell surface protein with a death domain that has functional similarities to TNFR1 and CD95. The ligand for DR-4 is TRAIL, and thus CD261 has also been called TRAIL-RI. CD261 is expressed in most human tissues. In contrast to CD95, TNFR1 and DR3 it does not use FADD to transmit death signals. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to CD261 (DR4) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.02% Sodium Azide - Immunogen
- Peptide from C-terminus of human CD261 (DR4)
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Frozen |  |
||
| Western Blotting | |
1/500 | 1/1000 |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Further Reading
-
Pan, G. et al. (1997) The receptor for the cytotoxic ligand TRAIL.
Science. 276 (5309): 111-3.
- Synonyms
- DR4
- TRAIL-R1
- RRID
- AB_2204665
- UniProt
- O00220
- Entrez Gene
- TNFRSF10A
- GO Terms
- GO:0016021 integral to membrane
- GO:0005035 death receptor activity
- GO:0006919 activation of caspase activity
- GO:0007250 activation of NF-kappaB-inducing kinase activity
- GO:0008134 transcription factor binding
- GO:0008625 induction of apoptosis via death domain receptors
- GO:0008656 caspase activator activity
- GO:0045569 TRAIL binding
View more products with CD261 specificity
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