CD107b antibody

Rabbit anti Human CD107b

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
CD107b

Product Code Applications Pack Size List Price Your Price Qty
AHP1634
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C WB 0.1 mg loader
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loader
Search for Batch Specific Datasheets

Rabbit anti Human CD107b antibody recognizes CD107b, also known as LAMP-2, a single-pass type I membrane protein belonging to the LAMP family. CD107b is a transmembrane glycoprotein associated with lysosomal membranes and is primarily expressed on mononuclear phagocytes. Expression of CD107b varies between cell populations and the molecular weight of CD107b can vary between 92-120 kDa. Rabbit anti Human CD107b antibody recognizes a band migrating at ~115 kDa in SDS page. CD107b is involved in a range of cellular processes including leukocyte adhesion (Kannan et al. 1996), protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome along with inter- and intracellular signal transduction (Eskelinen 2006). CD107b has also been implicated in tumor metastasis (Alessandrini et al. 2017).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human CD107b was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
Immunogen
A peptide corresponding to an 17 amino acid sequence from near the carboxyl terminus of human CD107b.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen 10ug/ml
Western Blotting 1.0 2.0ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
HepG2 cells
Western Blotting
AHP1634 detects a band of approximately 115kDa in HepG2 cell lysate.

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Synonyms
LAMP-2
RRID
AB_2280154
UniProt
P13473
Entrez Gene
LAMP2
GO Terms
GO:0005886 plasma membrane
GO:0002576 platelet degranulation
GO:0016021 integral to membrane
GO:0005624 membrane fraction
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0010008 endosome membrane
GO:0030168 platelet activation
GO:0031088 platelet dense granule membrane
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Human Products